Bile acids (BAs) can regulate their own metabolism and transport as well as other key aspects of metabolic homeostasis via dedicated (nuclear and G protein-coupled) receptors. Disrupted BA transport and homeostasis results in the development of cholestatic disorders and contributes to a wide range ...
Bile acids (BAs) can regulate their own metabolism and transport as well as other key aspects of metabolic homeostasis via dedicated (nuclear and G protein-coupled) receptors. Disrupted BA transport and homeostasis results in the development of cholestatic disorders and contributes to a wide range ...
1. Farnesoid X receptor and other nuclear bile acid receptors Bile acids (BA) not only serve as physicochemical detergents for lipid digestion and absorption but also have a broad spectrum of signaling properties regulating lipid and glucose homeostasis, thermogenesis, and liver regeneration, and have...
Digestive system cancers pose a significant global health challenge due to their high incidence and mortality rates [1,2,3,4,5]. Epidemiological analyses demonstrated that digestive system cancers, encompassing malignancies of the oesophagus, stomach, liver, pancreas, colon and rectum, significantly con...
The gut microbiota is involved in a number of different metabolic processes of the host organism, including the metabolism of xenobiotics. In our study, we focused on liver cytochromes P450 (CYPs), which can metabolize a wide range of exo- and endogenous
Rapid regulation of apolipoprotein B, E receptors, but not of apolipoprotein E receptors, by intestinal lipoproteins and bile acids J. Clin. Invest., 71 (1983), pp. 816-831 Google Scholar 20 Kita T., J.L. Goldstein, M.S. Brown, Y. Watanabe, C. Hornick, R.J. Havel Hepatic uptake ...
Bile acids (BA), long believed to only have lipid-digestive functions, have emerged as novel metabolic modulators. They have important endocrine effects through multiple cytoplasmic as well as nuclear receptors in various organs and tissues. BA affect multiple functions to control energy homeostasis, ...
Recently studies demonstrate that bile acids are also important signaling molecules that regulate body fat mass, lipid and glucose metabolism, and tissue insulin sensitivity. These effects of bile acids are mediated mainly by two bile acid receptors: TGR5 (GPBAR1), a G-protein coupled receptor; ...
Our understanding of how the microbiota affects the balance between response to and failure of cancer treatment by modulating the tumour microenvironment and systemic immune system has advanced rapidly in recent years. Microbiota-targeting interventions in patients with cancer are an area of intensive inv...
AhR activation by butyrate is independent of the SCFA receptors GPR41, GPR43, GPR109a and the SCFAs transporter MCT-1 Full size image Activation of the AhR signalling pathway by butyrate is independent of its role as inhibitor of HDAC