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Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets Article Open access 26 April 2024 The changing metabolic landscape of bile acids – keys to metabolism and immune regulation Article 04 April 2024 Revisiting the role of glucagon in health, di...
3.2.1 Intestinal flora affects diabetes development by regulating bile acid metabolism Bile acid is the metabolite of cholesterol in the liver. Bile acid metabolism is a complex process that requires cooperation between the liver and the intestinal flora (Zaborska and Cummings, 2018). The enzymes ...
Bile acids (BAs) are amphipathic steroid acids whose production and diversity depend on both host and microbial metabolism. These metabolites have emerged as biologically active signalling molecules that inform organs of nutrient availability. Their acti
TUDCA supplementation in experimental autoimmune encephalomyelitis reduced severity of disease through its effects on GPBAR1, based on behavioral and pathological measures. We demonstrate that bile acid metabolism is altered in MS; bile acid supplementation prevents polarization of astrocytes and microglia to...
Bile acids also are signaling molecules and inflammatory agents that rapidly activate nuclear receptors and cell signaling pathways that regulate lipid, glucose, and energy metabolism. The enterohepatic circulation of bile acids exerts important physiological functions not only in feedback inhibition of ...
Moreover, partial least square regression analysis (RLS-RA) showed that metabolism of glycerophospholipids (P2), bile acids (P4) and retinol (P5) was highly correlated with the clinical outcomes, suggesting they played key roles in the early stage of the liver injury. Our results also ...
展开 关键词: Ursodeoxycholic acid liver diseases skeletal muscle hepatobiliary cholestatic diseases cholestatic liver disease hydrophobic bile acid NUCLEAR RECEPTOR FXR FARNESOID-X-RECEPTOR SCLEROSING CHOLANGITIS ACTIVATION TGR5 MECHANISMS APOPTOSIS TRANSPORT TAUROURSODEOXYCHOLATE METABOLISM 年份: 2024 收藏...
Using Consensus clustering, the molecular subtypes related to bile acid metabolism were identified. The prognosis, clinicopathologic characteristics, immune landscape, and therapeutic response were compared between these subtypes. The single-cell RNA sequencing (scRNA-seq) analysis and preliminary cell ...
bile acidSREBPINSIGTGR5Cholesterol is an important component of lipids in animal membranes. All living cells can synthesize cholesterol, but the amount of synthesis is not sufficient, and therefore cholesterol synthesized in the liver is delivered to extrahepatic tissues as a form of LDL. The liver...