pathwaysThe human gut represents a complex ecosystem which harbours a diverse,predominantly anaerobic bacterial community.Intestinal microbiota are not just passive bystanders but active contributors to human metabolism interfering with numerous host metabolic pathways,which are necessary for the maintenance of...
Among the most abundant metabolites are the secondary bile acids deoxycholic acid (DCA) and lithocholic acid (LCA), which accumulate at concentrations of around 500 μM and are known to block the growth of Clostridium difficile1, promote hepatocellular carcinoma2 and modulate host metabolism via ...
Pharmaceutical activation of these bile-acid-signalling pathways is therefore a novel way to improve metabolism. Abstract Bile acids are increasingly being appreciated as complex metabolic integrators and signalling factors and not just as lipid solubilizers and simple regulators of bile-acid homeostasis....
Among the most abundant metabolites are the secondary bile acids deoxycholic acid (DCA) and lithocholic acid (LCA), which accumulate at concentrations of around 500 μM and are known to block the growth of Clostridium difficile1, promote hepatocellular carcinoma2 and modulate host metabolism via ...
Macronutrient, Energy, and Bile Acid Metabolism Pathways Altered Following a Physiological Meal Challenge, Relative to Fasting, among Guatemalan Adults 来自 国家科技图书文献中心 喜欢 0 阅读量: 17 作者:EA Yu,T Yu,DP Jones,R Martorell,M Ramirez-Zea,AD Stein ...
Low Nucleotide Variability of CYP51A1 in Humans: Meta-analysis of Cholesterol and Bile Acid Synthesis and Xenobiotic Metabolism Pathways. Lewiñska,Monika,UP Zmrzljak,... - 《Acta Chimica Slovenica》 被引量: 4发表: 2013年 Bile Acid Synthesis in Humans Has a Rapid Diurnal Variation That Is...
2. Bile acid metabolism 2.1. Bile acid synthesis in the liver In human liver, two primary bile acids, cholic acid (CA) and chenodeoxycholic (CDCA), are synthesized from cholesterol through two pathways (Fig. 1).1 The classic pathway is initiated by the rate-limiting enzyme cholesterol 7α-...
Fig. 1.The pathways of bile acids in terms of synthesis, storage, metabolism and excretion. The primary bile acids cholic acid (CA) and chenodeoxycholic acid (CDCA), are synthesized from cholesterol in the liver by the enzyme cholesterol 7 α-hydroxylase (CYP7A1). CA and DCA are eventually...
Y. L. Negative feedback regulation of bile acid metabolism: impact on liver metabolism and diseases. Hepatology 62, 1315–1317 (2015). PubMed Google Scholar Parks, D. J. Bile acids: natural ligands for an orphan nuclear receptor. Science 284, 1365–1368 (1999). CAS PubMed Google ...
Metabolism of Bile Acids. I. Absorption, Distribution, Excretion, and Metabolism of Ursodeoxycholic Acid Metabolism of Bile Acids. I. Absorption, Distribution, Excretion, and Metabolism of Ursodeoxycholic AcidThe fate after oral or intravenous administration of ... TAKAHIKO,HOSHITA,MAMI,... - 《...