Radominska A, Treat S, and Little J (1993) Bile acid metabolism and the pathophysiology of cholestasis. Semin Liver Dis 13:219 -234.Radominska A, Treat S, Little J. Bile acid metabolism and the pathophys- iology of cholestasis. Semin Liver Dis 1993;13:219 -234....
Metabolism of Bile Acids. I. Absorption, Distribution, Excretion, and Metabolism of Ursodeoxycholic Acid Metabolism of Bile Acids. I. Absorption, Distribution, Excretion, and Metabolism of Ursodeoxycholic AcidThe fate after oral or intravenous administration of ... TAKAHIKO,HOSHITA,MAMI,... - 《...
Among the most abundant metabolites are the secondary bile acids deoxycholic acid (DCA) and lithocholic acid (LCA), which accumulate at concentrations of around 500 μM and are known to block the growth of Clostridium difficile1, promote hepatocellular carcinoma2 and modulate host metabolism via ...
Pharmaceutical activation of these bile-acid-signalling pathways is therefore a novel way to improve metabolism. Abstract Bile acids are increasingly being appreciated as complex metabolic integrators and signalling factors and not just as lipid solubilizers and simple regulators of bile-acid homeostasis....
baicalensis treatment, which was primarily involved in glycerophospholipid metabolism, arachidonic acid metabolism and retinol metabolism pathways, with 536 extended... LH Men,PI Zi-Feng,HU Ming-Xin,... - 《Chinese Journal of Analytical Chemistry》 被引量: 0发表: 2021年 Metabolomics study of Angeli...
This kind of inhibition behaviour exerted cryptotanshinone concentrations-dependent and LCA concentrations-independent inhibition behaviour. CONCLUSION: All these data indicated the possibility of cryptotanshinone's influence towards bile acids metabolism and homeostasis of bile acids. 展开 ...
The use of animal models, especially genetically modified mice, plays an important role in studying the relationship between bile acid metabolism and human liver disease. In rodent livers, CDCA is hydroxylated at the 6β-position by CYP2C70 to α-muricholic acid (α-MCA) and ß-muricholic ...
Bile acid metabolism in liver pathobiology Bile acids facilitate intestinal nutrient absorption and biliary cholesterol secretion to maintain bile acid homeostasis, which is essential for protecting liver and other tissues and cells from cholesterol and bile acid toxicity. Bile a... JYL Chiang,JM Ferrel...
Through activating various signalling pathways, BAs not only regulate their own synthesis, enterohepatic recirculation and metabolism, but also immune homeostasis. This makes BAs attractive therapeutic agents for managing metabolic and inflammatory liver disorders. Recent experimental and clinical evidence ...
Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy Hu Wang Jiaxing Wang Ming Xu Nature Metabolism(2024) Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases Jian Sheng Loh Wen Qi Mak