Bile acid synthesis in primary cultures of rat and human hepatocytes. Ellis E,Goodwin B,Abrahamsson A,et al. Hepatology . 1998Ellis, E., Goodwin, B., Abrahamsson, A., Liddle, C., Mode, A., Rudling, M., et al. Bile acid synthesis in primary cultures of rat and human hepatocytes....
(intestinal inflammation),C-mannitol excretion in urine 0–2h (small intestinal permeability), fasting serum C4 (bile acid synthesis) and total and primary bile acid in stool samples during baseline, peri-transplant period (Days 5–7 after stem cell infusion), and after hematological recovery ...
Background:Bile acid synthesis, transport and metabolism are markedly altered in experimental cholestasis. Whether such coordinated regulation exists in human cholestatic diseases is unclear. We therefore investigated expression of genes for bile acid synthesis, detoxification and alternative basolateral export...
Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor. Hepatology 2003; 38: 930-938Ellis E, Axelson M, Abrahamsson A et al (2003) Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the...
Association of genes involved in bile acid synthesis with the progression of primary biliary cirrhosis in Japanese patients. J Gastroenterol. 2013;48:1160–70. 18. Shi TY, Zhang LN, Chen H, Wang L, Shen M, Zhang X, et al. Risk factors for hepatic decompensation in patients...
tu1262 obeticholic acid, a farnesoid x receptor agonist, reduces bile acid synthesis in patients with primary bile acid diarrhea-tu1262 obeticholic酸,法尼酯X受体激动剂,降低了胆汁酸合成原发性胆汁酸腹泻-知来论文发表中心DOI: 10.1016/S0016-5085(14)62881-X 被...
Seladelpar is a first-in-class oral, selective PPARδ agonist shown to regulate critical metabolic and liver disease pathways in indications with high unmet medical need. Preclinical and clinical data support its ability to regulate genes involved in bile ac...
In the setting of cholestasis, there is a reduction in bile acid production and, consequently, decreased intestinal absorption of cholesterol. It results in the endogenous synthesis of cholesterol in the liver and the secretion of very LDL. Moreover, as described ...
or delpar, for the treatment of primary biliary cholangitis (PBC). PPAR-delta has been shown to regulate critical metabolic and liver disease pathways. Preclinical and clinical data support its ability to regulate genes involved in bile acid synthesis, inflammation, ...
or as monotherapy in adults unable to tolerate UDCA.7Elafibranor exerts an effect on PPARα and PPARδ. Activation of PPARα and PPARδ decreases bile toxicity and improves cholestasis by modulating bile acid synthesis, detoxi...