Bile acid synthesis from cholesterol can occur via two pathways, one initiated by sterol 27-hydroxylase activity or one initiated by that of cholesterol 7 alpha-hydroxylase. In contrast to cholesterol 7 alpha-hydroxylase, which is found in the liver, sterol 27-hydroxylase is a widely distributed ...
Analysis of chenodeoxycholic acid, the predominant bile acid synthesized by Hep G2 cells in vitro, indicates its derivation from both pre-formed and newly synthesized cholesterol and that A ring transformation from cholesterol utilizes deuterium derived from water. Analysis of the bile acids derived ...
This review will focus on the regulation of bile acid synthesis in human livers and will address the species differences in regulation. BILE ACIDS ARE VERSATILE SIGNALING MOLECULES Bile acids are derived from cholesterol. Bile acid synthesis is the predominant metabolic pathway for catabolism of ...
Because of the number of enzymes committed to the formation of bile acids from cholesterol, it is possible that genetic or acquired defects in their synthesis may result in clinically apparent liver disease. 展开 关键词: Humans Bile Ducts Liver Cholestasis, Intrahepatic Xanthomatosis Cholesterol 7-...
The synthesis of teichoic acids. I. Polyglycerophosphate The first step in the degradation of the steroid side chain during biosynthesis of bile acids from cholesterol in man was studied in microsomal and mitocho... MM Burger,L Glaser - 《Journal of Biological Chemistry》 被引量: 261发表: ...
Regulation of cholesterol and bile acid synthesis in Hep G2 cells: Effect of cholesterol availability and bile acids: Internal Medicine, Modena Univesity ∗ Pharmacology, Milan Univesity, ItalyShow moreShow less Choose an option to locate/access this article: ...
Bile acids, which are synthesized from cholesterol in the liver [15, 16], initially yield chenodeoxycholic acid (CDCA) and cholic acid (CA) (Fig. 1). Following this, bile acids undergo conjugation with glycine or taurine before being stored and concentrated in the gallbladder. These bile acid...
Serum noncholesterol sterols and fecal elimination of cholesterol and plant sterols were quantitated by gas-liquid chromatography.RESULTSFecal losses of bile acids exceeded four to six times the control values, and cholesterol synthesis was increased two to three times. Cholesterol absorption efficiency ...
Cytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases. FEBS J. 279, 1516-1533.Lorbek, G., Lewinsha, M. and Rozman, D. (2012) Cytochrome P450s in the synthesis of cholesterol and bile acids - from mouse models to human diseases. FEBS J....
biogenesis around cholesterol, not only because this substance has received the major share of attention but also because cholesterol synthesis appears to be an integral part of the processes leading to the physiologically active steroids, namely, the bile acids, and the adrenocortical and sex ...