Bile acids are converted to their glycine and taurine N ‐acyl amidates by enzymes in the liver in a two‐step process. This conjugation reaction increases the aqueous solubility of bile acids, particularly in the acidic environment of the initial portion of the small intestine. In the first ...
Metabolic pathways involved in the conversion of cholesterol to cholic and chenodeoxycholic acids have been investigated in bile fistula patients treated with a number of labeled potential bile acid intermediates. The findings of the present report indicate that the human liver cell has the capacity to...
The ability of cultured hepatocytes to maintain a constant rate of bile acid synthesis and secretion in a chemically defined serum-free culture medium allowed us to examine the direct effects of bile acids on their synthesis. Mass quantitation of bile acids by gas liquid chromatography showed that...
To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option.doi:10.1002/chin.199551235U. MAITRADep. Org. Chem., Indian Inst. Sci., Bangalore 560 012, IndiaB. G. BAG...
The catabolism of cholesterol into bile acids is regulated by oxysterols and bile acids, which induce or repress transcription of the pathway's rate-limiting enzyme cholesterol 7α-hydroxylase (CYP7A1). The nuclear receptor LXRα binds oxysterols and mediates feed-forward induction. Here, we show...
Because of the number of enzymes committed to the formation of bile acids from cholesterol, it is possible that genetic or acquired defects in their synthesis may result in clinically apparent liver disease. 展开 关键词: Humans Bile Ducts Liver Cholestasis, Intrahepatic Xanthomatosis Cholesterol 7-...
In the last ten years mass spectrometry has grown to become one of the most valuable techniques for analysis and structure determination of bile acids. A very important reason for this development is the construction of combined gas chro... J Sjövall,P Eneroth,R Ryhage - Springer US 被引...
Production of bile acids (BAs), which facilitate digestion and absorption of nutrients, is a major regulator of this process. Here we identify a KLF15-Fgf15 signalling axis that regulates circadian BA production. Systemic Klf15 deficiency disrupted circadian expression of key BA synthetic enzymes, ...
Enhanced conversion of dietary cholesterol to bile acids through the alternative pathway leads to cold-associated, metabolically beneficial changes in the intestinal microbiome and to elevated bile acid levels that contribute to adaptive thermogenesis....
Various components of the enterohepatic circulation were investigated in 33 subjects to determine their effects on bile acid pool size. The pool size and secretion rates of bile acids were measured using an intestinal perfusion method, and bile acid synthesis was determined by fecal excretion. From ...