used were (1) reduction of the bile acids with NaBH4 to the corresponding bile alcohols, (2) selective tosylation of the terminal hydroxyl group, (3) iodination of the tosyl esters with NaI, and (4) treatment of the iodides with Na2SO3 to form the sulfonate analogs of the bile acids. ...
As very important sulfur-containing analogs of amino carboxylic acids, 2-aminoethanesulfonic acid was first isolated from ox bile in 19th century by Tiedemann and Gmelin, which name 'taurine' was attributed by Gmelin3,4. In addition, to be an essential amino acid of human body, taurine has ...
Generally the Formula IX compound, a base such as triethylamine and an activated trialkylsilyl compound (e.g., trimethylsilyl trifluoromethane sulfonate or trimethylsilyl chloride) are reacted in an aprotic, anhydrous solvent such as methylene chloride at a temperature less than about 10° C. for...
Synthesis of bile acid analogs: 7-alkylated chenodeoxycholic acids. Steroids. 53: 97-105.Une, M.; Yamanaga, K.; Mosbach, E. H.; Kuroki, S.; Hoshita, T. Synthesis of bile acid analogs: 7-alkylated chenodeoxycholic acids. Steroids 1989, 53, 97-105....
Michael J. JoyceS.V. HiremathMichael B. MattammalWilliam H. ElliottElsevier Inc.SteroidsJoyce et al., " Bile Acids. LXXIII. Synthesis of Analogs of 7alpha-Hydroxy-4-Cholesten-3-One as Substrates for Hepatic Steroid 12alpha-Hydroxylase, " Steroids, Jul. 1984;44(1):95-101....
(1) reduction of the bile acids with NaBH 4 to the corresponding bile alcohols, (2) selective tosylation of the terminal hydroxyl group, (3) iodination of the tosyl esters with NaI, and (4) treatment of the iodides with na 2 so 3 to form the sulfonate analogs of the bile acids. The...
Organic chemistry Synthesis and Characterization of Squalamine Analogs Based upon Bile Acids and Synthesis of a Fluorescent Squalamine Analog VILLANOVA UNIVERSITY Barry S. Selinsky GasslerFrank KAminosterols, where squalamine isolated from the tissues of the dogfish shark () is an example, are potent...
As very important sulfur-containing analogs of amino carboxylic acids, 2-aminoethanesulfonic acid was first isolated from ox bile in 19thcentury by Tiedemann and Gmelin, which name ‘taurine’ was attributed by Gmelin3,4. In addition, to be an essential amino acid of human body, taurine has ...
Figure 1. Chemical structure of CA-4, (I) and its analogs (II–IV). Figure 2. Structures of EGFR and CK1 inhibitors as potent anticancer agents. Another target for designing indole derivatives as anticancer agents is the family of protein kinase receptors. The epidermal growth factor recept...