P-value < 0.05) with the biosynthesis pathway of biotin (PWY-5005), which was also significantly lower in BDL mice. Two species from these butyrate-producing genera,Eubacterium sp. 14-2
However, the knockout of NLRP3 reversed these patterns.Conclusion (1) Primary conjugated bile acids increased in patients with liver fibrosis; (2) GCDCA induce hepatic fibrosis via the NLRP3 inflammasome pathway; (3) FXR inhibits NLRP3 activity by restraining its phosphorylation; (4) knockdown ...
The amount of total BA from the alternative pathway under normal human physiological conditions is less than 10%. The up-regulation of the alternative pathway may occur when the main pathway is fully or partially disturbed. Both CA and CDCA undergo conjugation reactions in the liver with taurine...
As seen inFig. 1A, the control liver tissues exhibited normal liver histology. In contrast, the liver sections from pediatric IF patients exhibited liver damages characterized by bile duct proliferation, lymphocytes infiltration, and hepatocyte ballooning (Fig. 1A). Apoptotic hepatocytes were detected b...
The FXR Agonist, Obeticholic Acid, Suppresses HCC Proliferation & Metastasis: Role of IL-6/STAT3 Signalling Pathway The nuclear receptor, farnesoid X receptor (FXR), has been recently considered as a tumor suppressor in HCC. IL-6/Janus kinase 2 (Jak-2)/signal transducer and activator of tr...
The findings of the present report indicate that the human liver cell has the capacity to synthesize both primary bile acids via multiple routes from cholesterol and 7 alpha-hydroxycholesterol. Evidence has been obtained for the existence of a major pathway to chenodeoxycholic acid via the 26-...
FXR-KLF11 regulated pathway has an essential role in the regulation of insulin transcription and secretion induced by glucose. Furthermore, FXR-SHP negative regulatory cascade can regulate gluconeogenesis in the liver. In addition, FXR activation also directly increases the expression of apolipoprotein ...
Rat Hepatocytes Transport Water Mainly via a Non-channel-mediated Pathway During bile formation by the liver, large volumes of water are transported across two epithelial barriers consisting of hepatocytes and cholangiocytes (i.e... Marinelli,A R. - 《Journal of Biological Chemistry》 被引量: ...
A GAPDH-Mediated Trans-Nitrosylation Pathway Is Required for Feedback Inhibition of Bile Salt Synthesis in Rat Liver GAPDH nitrosylation was assessed in normal and cholestatic rat and human livers. RESULTS: Rats placed on cholate-rich diets and given L-NAME had increased... CM Rodriguez-Ortigosa,...
which migrates to the liver and facilitates inhibition of the rate-limiting enzyme Cyp7a1 to reduce bile acid synthesis via the classical pathway46. However, while trending greater relative to DIO, the enhanced expression of FXR in GB-IL mice was not significant. We also did not detect in ...