Formula I substituted bicyclic β- lactam compound, (I) is a β- lactamase inhibitor, wherein a, X, R1 and R2 are as defined in the present invention. 该化合物及其药学可接受的盐可以与β-内酰胺类抗生素联合用于治疗细菌感染. The compounds and pharmaceutically acceptable salts thereof may be ...
(redirected fromBeta-lactam antibiotics) Medical Encyclopedia Related to Beta-lactam antibiotics:beta-lactamase,Aminoglycosides n. Any of a class of broad-spectrum antibiotics, such as the penicillins and the cephalosporins, that contain a beta-lactam ring. ...
Beta-lactamase inhibitors are agents that enhance the effectiveness of beta-lactam antibiotics against bacteria producing beta-lactamases by causing irreversible inhibition of these enzymes. AI generated definition based on: xPharm: The Comprehensive Pharmacology Reference, 2007 ...
: any of a large class of natural and semisynthetic antibiotics (as the penicillins and cephalosporins) with a lactam ring Dictionary Entries Near beta-lactam beta interferon beta-lactam beta-lactamase See More Nearby Entries Cite this Entry Style “Beta-lactam.” Merriam-Webster.com ...
BETA-LACTAMASE: The capacity to produce beta-lactamase, an enzyme which hydrolyses penicillin and cephalosporines, is the main source of bacterial resistance to beta-lactamines, thus the important contribution of beta-lactamase inhibitors (clavanulanic acid, sulbactam and tazobactam). MECHANISM OF ACTI...
Administration of the beta-lactam antibiotic/beta-lactamase inhibitor mixture proved to be more effective against the resistant strains than the antibiotics alone. Polymyxins Polymyxins are peptide antibiotics active against gram-negative bacteria. All polymyxins contain the fatty acid D-6-methyloctan-1-...
In the search for the mechanisms behind this increasingly prevalent form of resistance, microbiologists have identified a new type of beta-lactamase enzyme, called inhibitor-resistant TEMs (IRTs), which can withstand the effects of beta-lactamase inhibitor compounds, further reducing the arsenal of ...
The identification of new metallo-β-lactamase inhibitor leads from fragment-based screening The emergence of metallo-β-lactamases (MBLs) capable of hydrolysing a broad spectrum of β-lactam antibiotics is particularly concerning for the future tr... Peter,Vella,and,... - 《Bioorganic & Medicina...
A novel beta-lactamase inhibitor has been isolated from Streptomyces clavuligerus ATCC 27064 and given the name clavulanic acid. Conditions for the cultiva... C Reading,M Cole - 《Antimicrob Agents Chemother》 被引量: 1051发表: 1977年 Monotherapy versus beta-lactam-aminoglycoside combination treatment...
Beta-lactamases are the commonest cause of bacterial resistance to beta-lactam antibiotics. They have been classified phenotypically by their isoelectric p... B Bedenić - 《Lijec̆nic̆ki Vjesnik》 被引量: 3发表: 2004年 Extended-spectrum beta-lactamase in the urinary isolates of Enterobacte...