In particular, this disclosure provides DBO compounds that, when used in the disclosed Synergy MIC Assay with a β-lactam antibiotic at a fixed concentration have an MIC of 8 μg/mL or less against one or more isogenic β-lactamase expressing bacterial strains.Yu Gui Gu...
待解决 悬赏分:1 - 离问题结束还有 beta-lactamase inhibitors问题补充:匿名 2013-05-23 12:21:38 β-内酰胺酶抑制剂 匿名 2013-05-23 12:23:18 Beta-lactamase服用血管紧张素转化酶抑制剂 匿名 2013-05-23 12:24:58 betalactamase抗化剂 匿名 2013-05-23 12:26:38 β-内酰胺酶抑制剂 匿...
Disclosed herein are α-aminoboronic acids and their derivatives which act as inhibitors of beta-lactamases. Also disclosed herein are pharmaceutical compositions comprising α-aminoboronic acids and methods of use thereof. Inventors: Burns, Christopher J. (Malvern, PA, US) Jackson, Randy W. (Gl...
BETA-LACTAMASE: The capacity to produce beta-lactamase, an enzyme which hydrolyses penicillin and cephalosporines, is the main source of bacterial resistance to beta-lactamines, thus the important contribution of beta-lactamase inhibitors (clavanulanic acid, sulbactam and tazobactam). MECHANISM OF ACTI...
Beta-lactamase inhibitors 优质文献 相似文献Beta-lactamase inhibitors: the story so far. The inhibitory activity of five beta-lactam agents, alone and in combination with a beta-lactamase inhibitor, was compared with that of cefoxitin and metro... ...
Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also pro...
Beta-lactamase inhibitors: agents to overcome bacterial resistance. The extensive use of beta-lactam antibiotics in hospitals and community has created major resistance problems leading to increased morbidity, mortality and... SN Maiti,OA Phillips,RG Micetich,... - 《Curr.med.chem》 被引量: 153...
专利名称:BETA-LACTAMASE INHIBITORS 发明人:BURNS, Christopher, J.,GOSWAMI, Rajesh,JACKSON, Randy, W.,LESSEN, Thomas,LI, Weiping,PEVEAR, Daniel,TIRUNAHARI, Pavan, Kumar,XU, Hongyu 申请号:EP 2010/0564 08 申请日:20100511 公开号:WO2010/130708A9 公开日:20110113 摘要:Disclosed herein are α-amino...
Beta-lactamase inhibitors which are 6-alpha- and 6-beta- (aminomethyl) and (1-aminoethyl)pencillanic acid 1,1-dioxides; pharmaceutically- acceptable salts thereof; conventional esters thereof which are hydrolyzable in vivo; bis-methanedi... WE Barth - US 被引量: 24发表: 1984年 Activity of...
BETA-LACTAMASE INHIBITORS 专利名称：BETA-LACTAMASE INHIBITORS 发明人：Yu Gui Gu,Yong He,Ning Yin,Dylan C.Alexander,Jason B. Cross,Robert Busch,Roland E. Dolle,Chester A. Metcalf, III 申请号：US14216476 申请日：20140317 公开号：US20140316133A1 公开日：20141023 专利内容由知识产权出版社提供 摘要：...