In particular, the compounds can be in the β- lactam antibiotics (eg, imipenem, piperacillin or ceftazidime) together for confrontation since the inner β- lactamase presence within β- lactam antibiotic resistance microorganisms.T·A·布利扎德...
Beta-lactam antibiotics beta-lactam inhibitors Beta-lactam Ring Beta-lactam Ring Beta-lactam Ring Beta-Lactam Ring Records beta-lactamase beta-lactamase beta-lactamase beta-lactamase inhibitors Beta-Lactamase Negative Ampicillin-Resistant Beta-Lactamase Producing Organism ...
Beta-lactamaseinhibitors bind irreversibly to the catalytic site of beta-lactamase, preventing hydrolysis of the beta-lactam antibiotic. They also bind to bacterialpenicillinbinding proteins, increasing theantibacterial activityof the antibiotics.Clavulanic acidhas a chemical structure resembling the penicillin...
To prevent the destruction of these drugs by beta-lactamases, these antibiotics are very often administered with beta-lactamase inhibitors. Other modes of beta-lactam resistance by Acinetobacter include modification of penicillin binding proteins and the presence of drug efflux pumps Katzung (2001). ...
BETA-LACTAMANTIBIOTICS(inhibitorsofcellwallsynthesis)Theirstructurecontainsabeta-lactamring.Themajorsubdivisionsare:(a)penicillinswhoseofficialnamesusuallyincludeorendin“cillin”(b)cephalosporinswhicharerecognizedbytheinclusionof“cef”or“ceph”intheirofficialnames.(c)carbapenems(e.g.meropenem,imipenem)(d)mono...
beta-Lactamases constitute the major defense mechanism of pathogenic bacteria against beta-lactam antibiotics. When the beta-lactam ring of this antibiotic... K Bush - 《Clinical Microbiology Reviews》 被引量: 235发表: 1988年 Comparative activities of the beta-lactamase inhibitors YTR 830, clavulanate...
Inhibitors of Cell Wall Synthesis: Beta lactams antibiotics Dr. Lei Shen Dept. of Pharmacology Aims and requirements 1. To master the mechanism of action and the bacterial resistance of β-lactam antibiotics. 2. To master the antibacterial spectrum, clinical use, adverse reactions and prophylactic ...
beta-lactamase (redirected fromBetalactamase) Thesaurus Medical Encyclopedia Related to Betalactamase:ESBL be·ta-lac·ta·mase (bā′tə-lăk′tə-mās′, -māz′, bē′-) n. Any of various enzymes that hydrolyze and inactivate beta-lactam antibiotics such as penicillin, found in many an...
Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain
The resistance of bacteria to the normally lethal action of beta-lactam antibiotics is largely due to the production of beta-lactamases that catalyze the hydrolysis of the beta-lactam. One class of these enzymes is a zinc-dependent metallo-beta-lactamase for which there are no clinically available...