(redirected fromBeta-lactam antibiotics) Medical Encyclopedia Related to Beta-lactam antibiotics:beta-lactamase,Aminoglycosides n. Any of a class of broad-spectrum antibiotics, such as the penicillins and the cephalosporins, that contain a beta-lactam ring. ...
Prescott, John FPrescott JF. In: Other β-lactam antibiotics: Beta-lactamase inhibitors, carbapenems, and monobactams. Giguere S, Prescott JF, Dowling PM, editors. John Wiley & Sons; New York: 2013. pp. 175-188.
The resistance of bacteria to the normally lethal action of beta-lactam antibiotics is largely due to the production of beta-lactamases that catalyze the hydrolysis of the beta-lactam. One class of these enzymes is a zinc-dependent metallo-beta-lactamase for which there are no clinically available...
antibioticsChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via...
Beta Lactamase TEM 1 is an enzyme encoded by the bla gene in E. coli, with its expression being constitutive. The resistance to β-lactam antibiotics is directly proportional to the number of copies of the bla gene and the enzyme synthesized. ...
Targeted treatment of infections reduces the use of broad-spectrum antibiotics, and thus also the selection of resistant bacteria. Antibiotic resistance can be reduced. The cost to the population as a whole and to the health care system is lowered by the reduction in the use of expensive broad...
At present, the widespread of extended-spectrum β-lactamase (ESBL)- and carbapenemase-producing organisms pose a serious challenge for clinical management and public health for their hydrolytic activity against expanded-spectrum of β-lactam antibiotics9,12,13. Hospital wastewater is a complex ...
WHO publishes list of bacteria for which new antibiotics are urgently needed, http://www.who.int/ mediacentre/news/releases/2017/bacteria-antibiotics-needed/en/ (2017). 4. Bush, K. Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae. Curr Opin Microbiol. 13, 558–...
Clavulanic acid is a potent in- hibitor of the β-lactamases and is commonly included with β-lactam antibiotics when an ESBL-producing bacterium is suspected. Clavulanic acid is a member of the clavams or oxapenams that inhibits β-lactamase activity by cova- © 2013 Newire et al.; ...
Antibiotics, beta-lactamase inhibitorsdoi:US4923856 Aare novel compounds which exhibit β-lactamase inhibitory action and have antibacterial properties.Nigel J. P. BroomGerald BrooksSteven CoultonUS