The meaning of BETA-LACTAM is any of a large class of natural and semisynthetic antibiotics (as the penicillins and cephalosporins) with a lactam ring.
Beta-lactam antibiotics beta-lactam inhibitors Beta-lactam Ring Beta-lactam Ring Beta-lactam Ring Beta-Lactam Ring Records beta-lactamase beta-lactamase beta-lactamase beta-lactamase inhibitors Beta-Lactamase Negative Ampicillin-Resistant Beta-Lactamase Producing Organism ...
Treatment options for infections caused by MDR-GN remain scarce and only few new substances are currently in clinical phaseII/III studies or have already been granted market approval.ObjectivesTo provide an overview about current data on new -lactam antibiotics and -lactamase inhibitor combinations, ...
Cefotaxime and Ceftriaxone show good activity against streptococci, gonococci, meningococci, Haemophilus, and staphylococci. High β-lactamase resistance. Weak activity against Pseudomonas. No activity against enterococci, mycoplasma, chlamydia, and multidrug-resistant Staphylococcus aureus. Urologic Indications ...
The resistance of bacteria to the normally lethal action of beta-lactam antibiotics is largely due to the production of beta-lactamases that catalyze the hydrolysis of the beta-lactam. One class of these enzymes is a zinc-dependent metallo-beta-lactamase for which there are no clinically available...
Beta Lactamase TEM 1 is an enzyme encoded by the bla gene in E. coli, with its expression being constitutive. The resistance to β-lactam antibiotics is directly proportional to the number of copies of the bla gene and the enzyme synthesized. ...
A pharmaceutical composition, including: at least one β-lactam antibiotic, at least one β-lactamase inhibitor, and at least one buffer component. The composition can be formulated with at least one of aminoglycoside antibiotics into solution for controlling microbial infection in a container....
Sensitivity to beta-lactam antibiotics and production of beta-lactamase of gram-negative clinical isolatesMan'ko VM, Petrov RV, Sidorovich IG, Kraskina NA.doi:10.1007/BF00404587J. L. HoekstraA. W. HoubenE. E. StobberinghC. P. A. van Boven...
Xanthomonas campestris pv. campestris β-lactamase ampR bla LysR-motif 1. Introduction Penicillin was discovered in 1928 and used to treat bacterial infections during World War II. Since then, numerous natural and synthetic β-lactam antibiotics have been introduced into the pharmacotherapeutic market ...
Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the intensive care unit (ICU). ICU patients present many pathophysiological features that cause pharmacokinetic (PK) and pharmacodynamic (PD) specificities, leading to the risk of u