Beta-Lactamases of Ambler's Class A are the most commonly encountered mechanism of bacterial resistance to beta-lactam antibiotics. In the face of selective pressure arising from use of either newer cephalosporins or beta-lactam/beta-lactamase inhibitor combinations, mutations arose among Class A beta...
www.nature.com/scientificreports OPEN A new class A beta‑lactamase gene blaCAE‑1 coexists with blaAFM‑1 in a novel untypable plasmid in Comamonas aquatica Ying Li 1,2, Chengju Fang 1, Xu Wang 1, Qian Liu 3, Yichuan Qiu 1, Xiaoyi Dai 1...
The catalytic function of β-lactamases is the primary mechanism of bacterial resistance to β-lactam antibiotics (penicillins, cephalosporins, carbapenems). β-lactamases hydrolyze the β-lactam bond of these antibiotics, a structure modification that abrogates the antibacterial activity. β-lactams incl...
Bacterial production of beta-lactamases, which hydrolyze beta-lactam type antibiotics, is a common antibiotic resistance mechanism. Antibiotic resistance is a high priority intervention area and one strategy to overcome resistance is to administer antibiotics with beta-lactamase inhibitors in the treatment ...
Understanding the mechanisms by which beta-lactamases destroy beta-lactam antibiotics is potentially vital in developing effective therapies to overcome bacterial antibiotic resistance.Class A beta-lactamases are the most important and common type of these enzymes.A key process in the reaction mechanism of...
Mechanisms of antibiotic resistance: QM/MM modeling of the acylation reaction of a class A beta-lactamase with benzylpenicillin. Understanding the mechanisms by which beta-lactamases destroy beta-lactam antibiotics is potentially vital in developing effective therapies to overcome ba... Johannes,C,Hermann...
*, Junghyun Hwang1, Fabio Prati3, Thinh-Phat Cao2, Sung Haeng Lee2 & Heenam Stanley Kim1 The omega loop in β-lactamases plays a pivotal role in substrate recognition and catalysis, and some mutations in this loop affect the adaptability of the enzymes to new antibiotics....
Class A β-lactamases-enzyme-inhibitor interactions and resistance - novel TEM-enzyme conferring resistance to β-lactamase inhibitors β-Lactamases of Ambler's Class A are the most commonly encountered mechanism of bacterial resistance to β-lactam antibiotics. In the face of selective pressure arising...
Carbapenem antibiotics are used as antibiotics of last resort because they possess a broad spectrum of antimicrobial activity and are not easily hydrolyzed by beta-lactamases. Recently, class A enzymes, such as the SME-1, NMC-A, and IMI-1 beta-lactamases, have been identified with the capacity...
The rapid accumulation of resistance mechanisms to multiple antibiotic classes and the global spread of CRAB has rendered this preferred class of antibiotics obsolete7. Increasingly, the emergence of pan-drug-resistant A. baumannii has been documented8,9. Recent approvals of the siderophore-conjugated...