Beta-lactamase inhibitorsELSEVIERMeyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (Fifteenth Edition)
Drugs have therefore been developed that inhibit beta-lactamase, as a way of overcoming this resistance [1]. They are beta-lactam compounds with particularly high affinities for beta-lactamases [2,3], which therefore act as competitive inhibitors of beta-lactamases. Beta-lactamase inhibitors have ...
(redirected from beta-lactamase resistance)Also found in: Thesaurus, Medical, Legal, Financial, Encyclopedia. re·sis·tance (rĭ-zĭs′təns) n. 1. The act or an instance of resisting or the capacity to resist. 2. A force that tends to oppose or retard motion. 3. often ...
Related to beta-lactam:beta-lactamase,Beta-lactam Ring be·ta-lac·tam (bā′tə-lăk′təm, bē′-) n. 1.A lactam composed of a four-membered ring, formed by intramolecular condensation of an amino acid in which the amino group is located at the beta position, or any compound ...
Microbiocides, beta-lactamase inhibitors The compounds have antimicrobial and/or β-lactamase-inhibitory activity and are of value as drugs for human beings and domesticated animals. S Kishimoto,T Matsuo,M Ochiai - US 被引量: 22发表: 1989年 Stability of beta-lactamase inhibitors and beta-lactam ...
(d)monobactams(e.g.aztreonam)(e)beta-lactamaseinhibitors(e.g.clavulanicacid,sulbactam).A.FLEMING(1881–1955)•PenicillinG-P.notatum I.PENICILLINS (1929)Thecellwallcompletelysurroundsthecytoplasmicmembrane,maintainscellshapeandintegrity,andpreventscelllysisfromhighosmoticpressure.Thecellwalliscomposedofa...
and β-lactamase inhibitors. These drugs block cell wall synthesis by preventing accurate working of the Penicillin-binding protein (PBP), which has a principal role in the synthesis of the bacterial cell wall, and finally leads to cellular death. Nevertheless, it is unfortunate that, in recent...
Microbiocides, beta-lactamase inhibitors The compounds have antimicrobial and/or β-lactamase-inhibitory activity and are of value as drugs for human beings and domesticated animals. S Kishimoto,T Matsuo,M Ochiai - US 被引量: 22发表: 1989年 ...
References: Karen Bush and Patricia A. Bradford β-Lactams and β-Lactamase Inhibitors: An Overview. Cold Spring Harb Perspect Med. 2016 Aug; 6(8): a025247. U.S. Food & Drug Administration (FDA). (2022). Non-Penicillin Beta-Lactam Drugs: A CGMP Framework for Preventing Cross-Contamination...
lactamaseinhibitor combinations. Each of these subgroups consists of a beta-lactam ring plus a connectedthiazolidinering with the addition of a side chain (Beauduy & Winston, 2020a). This side-chain helps dictate theantibacterial activityand pharmacologic properties of each set of drugs (Macdougall...