In particular, this disclosure provides DBO compounds that, when used in the disclosed Synergy MIC Assay with a β-lactam antibiotic at a fixed concentration have an MIC of 8 μg/mL or less against one or more isogenic β-lactamase expressing bacterial strains.Yu Gui Gu...
待解决 悬赏分:1 - 离问题结束还有 beta-lactamase inhibitors问题补充:匿名 2013-05-23 12:21:38 β-内酰胺酶抑制剂 匿名 2013-05-23 12:23:18 Beta-lactamase服用血管紧张素转化酶抑制剂 匿名 2013-05-23 12:24:58 betalactamase抗化剂 匿名 2013-05-23 12:26:38 β-内酰胺酶抑制剂 匿...
BETA-LACTAMASE: The capacity to produce beta-lactamase, an enzyme which hydrolyses penicillin and cephalosporines, is the main source of bacterial resistance to beta-lactamines, thus the important contribution of beta-lactamase inhibitors (clavanulanic acid, sulbactam and tazobactam). MECHANISM OF ACTI...
Disclosed herein are α-aminoboronic acids and their derivatives which act as inhibitors of beta-lactamases. Also disclosed herein are pharmaceutical compositions comprising α-aminoboronic acids and methods of use thereof. Inventors: Burns, Christopher J. (Malvern, PA, US) Jackson, Randy W. (Gl...
beta-lactamase inhibitors Beta-Lactamase Negative Ampicillin-Resistant Beta-Lactamase Producing Organism beta-lactamase resistance beta-lactamase resistant penicillin beta-lactamase resistant penicillin beta-lactamase resistant penicillin Beta-Lactamase-Positive Amoxicillin/Clavulanate-Resistant Beta-Lactamase-Producing ...
Beta-lactamase inhibitors are agents that enhance the effectiveness of beta-lactam antibiotics against bacteria producing beta-lactamases by causing irreversible inhibition of these enzymes. AI generated definition based on: xPharm: The Comprehensive Pharmacology Reference, 2007 ...
The β-Lactamase Inhibitor Screening Kit is a rapid, simple and sensitive assay that is suitable for high throughput screening of β-Lactamase inhibitors. βL activity is measured by hydrolyzing a chromogenic cephalosporin called nitrocefin, producing a colorimetric product (A490), proportional to the...
BETA-LACTAMASE INHIBITORS 专利名称：BETA-LACTAMASE INHIBITORS 发明人：Yu Gui Gu,Yong He,Ning Yin,Dylan C.Alexander,Jason B. Cross,Robert Busch,Roland E. Dolle,Chester A. Metcalf, III 申请号：US14216476 申请日：20140317 公开号：US20140316133A1 公开日：20141023 专利内容由知识产权出版社提供 摘要：...
专利名称:BETA-LACTAMASE INHIBITORS 发明人:BURNS, Christopher, J.,GOSWAMI, Rajesh,JACKSON, Randy, W.,LESSEN, Thomas,LI, Weiping,PEVEAR, Daniel,TIRUNAHARI, Pavan, Kumar,XU, Hongyu 申请号:EP 2010/0564 08 申请日:20100511 公开号:WO2010/130708A9 公开日:20110113 摘要:Disclosed herein are α-amino...
Resistance to beta-lactams mediated by beta-lactamases can be overcome successfully with the use of beta-lactamase inhibitors. The combination of beta-lactams with beta-lactamase inhibitors restores the activity of the beta-lactams, allowing their continued clinical use. The development of beta-...