METALLO-BETA-LACTAMASE INHIBITORSThe present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.ベネット,フランク...
英文:Metallo-beta-lactamase 中文:金属-内酰胺酶 例句:Class B metallo-β-lactamases (MBLs) have a broad substrate spectrum and can catalyze the hydrolysis of virtually all β-lactam antibiotics with the exception of monobactams. They are not ...
4-Butyl-3-methylphthalic acid was recognized as a metallo-beta-lactamase inhibitor. The structure-activity relationship study of substituted phthalic acids afforded 3-phenylphthalic acid derivatives as potent IMP-1 inhibitors. On the other hand, 3-substi
Homo-cysteinyl peptide inhibitors of the L1 metallo-beta-lactamase, and SAR as determined by combinatorial library synthesis. Homo-cysteinyl peptides were found to be more active than cysteinyl peptides toward L1 metallo-β-lactamase as reversible competitive inhibitors. A combina... S Qin,A Law...
1) and its stereoisomers were reported as broad‐spectrum inhibitors to subclass B1, B2, and B3 MBLs, especially with submicromolar potency to multiple B1 MBL enzymes (Bacillus cereus (Bcll), NDM-1 and VIM-2) [18]. The corresponding d-stereoisomer (1) is a more potent...
Norfloxacin is a nalidixic acid analogue and one of the most potent DNA gyrase inhibitors. To study the mechanism of this important class of inhibitors, th... LL Shen,AG Pernet - 《Proc Natl Acad Sci U S A》 被引量: 649发表: 1985年 ...
The long-term objective of the proposed research is the rational design and preparation of irreversible inhibitors of the Zn(II)-containing beta-lactamases. Given the apparent structural and mechanistic differences among the metallo-beta-lactamases, this objective can only be realized after detailed ...
Structure-BasedVirtualScreeningfortheDiscoveryofNovelInhibitorsofNewDelhiMetallo-β-lactamase‑1FrancescaSpyrakis,†,⊥GiuseppeCelenza,‡FrancescaMarcoccia,‡MatteoSantucci,†SimonCross,§PierangeloBellio,‡LauraCendron,∥MariagraziaPerilli,‡andDonatellaTondi*,††DipartimentodiScienzedellaVita,...
Abstract: The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.Inventors: Tang, Haifeng (Metuchen, NJ, US) Yang, Shu-wei (...
Carbapenem Derivatives as Potential Inhibitors of Various β-Lactamases, Including Class B Metallo-β-Lactamases A variety of 1β-methylcarbapenem derivatives were screened to identify inhibitors of IMP-1 metallo-β-lactamase, a class B β-lactamase, in an automated m... Rie,Nagano,Yuka,... -...