PROBLEM TO BE SOLVED: To provide inhibitors of metallo-β-lactamase that degrades β-lactams that inhibit cell wall synthesis, and therapeutic agents comprising the inhibitors against β-lactamase-producing bacteria.大村 智塩見 和朗浅見 行弘鹿島 由衣野中 健一花木 秀明...
Yong, D.et al. Characterization of a new metallo-beta-lactamase gene,bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure inKlebsiella pneumoniaesequence type 14 from India.Antimicrob. Agents Chemother.53, 5046–5054 (2009). ArticleCASPubMedPubMed CentralGoogl...
Analysis of two clonally related multiresistant Pseudomonas aeruginosa isolates led to the identification of a novel IMP-type metallo-β-lactamase. IMP-29 was significantly different from the other IMP variants (the closest variant being IMP-5 with 93% amino acid identity). The bla(IMP-29) gene...
Carbapenemases of Chryseobacterium (Flavobacterium) meningosepticum: Distribution of blaB and Characterization of a Novel Metallo-beta -Lactamase Gene, bla... (Flavob-acterium) meningosepticum:distribution of blab and characterization of a novel Metallo-β-Lactamase gene,blaB3, in the type strain,...
New β-lactam (BL)/β-lactamase inhibitor (BLI) combinations recently approved are active against KPC and some OXA-48 producers, but not against isolates producing metallo-β-lactamases (MBLs). We evaluated the activity of QPX7728 (QPX), a novel BLI paired with various BLs against a ...
Characterization of novel plasmid-mediated /Hactamases (SHV-167 and ACT-16) associated with New Delhi metallo-beta-lactamase-1 harbouring isolates from neo... Saha, S. Basu, Characterization of novel plasmid-mediated b-lactamases (SHV-167 and ACT-16) associated with New Delhi metallo-b-lactam...
Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture. Bacterial expression of beta-lactamases is the most widespread resistance mechanism to beta-lactam antibiotics, such as penicillins and cephalosporins. The.....
A. Interplay between beta-lactamases and new beta-lactamase inhibitors. Nat. Rev. Microbiol. 17, 295–306. https://doi.org/10.1038/s41579-019-0159-8 (2019). 10. Bonomo, R. A. Beta-lactamases: A focus on current challenges. Cold Spring Harb. Perspect. Med...
Metallo-beta-lactamase superfamily; Metallo-beta-lactamase superfamily; Apart from the beta-lactamases a number of other proteins contain this domain. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D- lactoyl-glutathione to form glutathione...
Tazobactam is a sulfone derivative of penicillanic acid [17]. Like other early β-lactamase inhibitors (e.g., clavulanic acid, sulbactam), the moiety at position 1 (a sulfone group in tazobactam) acts as a leaving group that promotes secondary ring opening at the β-lactamase active site,...