The complexed structure and antimicrobial activity of a non-beta-lactam inhibitor of AmpC _beta- lactamase. Protein Sci 1999; 8 : 2330-7.Powers, R. A.; Blazquez, J.; Weston, G. S.; Morosini, M. I.; Baquero, F.; Shoichet, B. K. The complexed structure and anti- microbial ...
aeruginosaand avibactam is a novel nonbeta-lactam beta-lactamase inhibitor. Avycaz®, the trade name for this new combination antibiotic, restores the activity of ceftazidime against some of the previously resistant pathogens. Avycaz was approved in 2015 for the treatment of complicated urinary tract...
aeruginosa to the three beta-lactam/beta-lactamase inhibitor combination drugs studied. Periodic susceptibility testing should be carried out over a period of... U Farwa,I Mirza,S Abbasi,... 被引量: 0发表: 2018年 Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isola...
Beta-lactam antibiotics in combination with novel β-lactamase inhibitors - an alternative therapy for infections caused by multidrug-resistant bacteria Introduction: New combinations of old 尾-lactam drugs with novel 尾-lactamase inhibitors, approved in recent years by the US Food and Drug Administratio...
Transition-state analog inpressing need for novel, non-lactam drugs. A datahibitors (Figure 1C), such as boronic acids and phosphobase of over 200,000 compounds was docked to the nates, inhibit both class A and class C -lactamases active site of AmpC -lactamase to identify potential [4...
3, Jun Cheng1, Li-fen Hu1, Tai Ma1, Jun Yin1, Ying Ye1,2 and Jia-Bin Li1,2 The purpose of this study was to investigate the phenotypic and molecular characterization of a novel plasmid-mediated AmpC-type b-lactamase in Klebsiella pneumoniae E701 isolated from Anhui province in China....
The present disclosure provides novel deuterated alpha-(N-sulfonamido)acetamide compounds, their pharmaceutical composition, processes thereof and a method for the treatment of Alzheimer's disease, head trauma, traumatic brain injury, and/or dementia pugilistica and/or other conditions associated with ...
Inhibitory effect of JS-1 on b-lactamase As the examined alkaloid has been shown to inhibit DD-peptidase 64-575 II activity, similar to clavulanic acid,9 which is a known inhibitor of b-lactamases, an inhibition test was carried out for this enzyme. JS-1 did not show inhibitory activity ...
We reveal connections between β-lactam susceptibility, peptidoglycan synthesis, and blockages in undecaprenyl phosphate metabolism. The synergy of the β-lactam/β-lactamase inhibitor combination ceftazidime/avibactam is primarily mediated by inhibition of the PenB carbapenemase. In comparison with ...
Several cases in which a combination of two different molecules elicit synergistic biological activities have been noted. A well-known case is the use of a β-lactam and a β-lactamase inhibitor. The combination potentiates the antibacterial activity of β-lactam against β-lactam-resistant bacteria...