Avibactam is a covalent, reversible, non-beta-lactam beta-lactamase inhibitor. Proc Natl Acad Sci U S A. 2012;109:11663-11668.Ehmann, D. E. et al. Avibactam is a covalent, reversible, non-beta-lactam beta-lactamase inhibitor. Proceedings of the National Academy of Sciences of the United...
Ceftazidime/avibactam: a novel cephalosporin/nonbeta-lactam beta-lactamase inhibitor for the treatment of complicated urinary tract infections and complicated ... V Celeste,H Jose,A Nishaal - 《Drug Design Development & Therapy》 被引量: 9发表: 2016年 Ceftazidime–avibactam: novel antimicrobial combi...
A resurgence of β-lactamase inhibitor combinations effective against multidrug-resistant Gram-negative pathogens 尾-Lactamase inhibitors (BLIs) have played an important role in combatting 尾-lactam resistance in Gram-negative bacteria, but their effectiveness has dimi... K Bush - 《International Journal...
A non-beta-lactam antibiotic inhibitor for enterohemorrhagic Escherichia coli O104:H4Dynamic simulationβ-LactamaseE. coliO104: H4Non-β-lactam inhibitorThe overuse of antibiotics has caused an increased prevalence of drug-resistant bacteria. Bacterial resistance in E. coliis regulated via production ...
This thought led to the development of Avibactam, a Diazabicyclooctane compound, which was approved by FDA in February 2016 as the first non-lactam ß-lactamase inhibitor to be used to treat complex intra-abdominal infections in combination with ceftazidine and metrodinazole. Another chemically...
We gave intravenous infusions of sulbactam, a beta-lactamase inhibitor, in combination with ampicillin or cephalothin to women 2 days after cesarean section delivery. The elimination t1/2 was 1.0 hours, the volume of distribution at stea... G Foulds,RD Miller,AK Knirsch,... - 《Clinical Pha...
The intrinsic resistance to β-lactam antibiotics was due mainly to the presence of a chromosomally-encoded gene (blaC) in M. tuberculosis for a Class A, Ambler β-lactamase (BlaC). The BlaC enzyme has already been validated as one of the leading targets of tuberculosis therapy. In the ...
A primary contributor to its ability to resist 尾-lactam antibiotics is the expression, following detection of the 尾-lactam, of the AmpC 尾-lactamase. As AmpC e... SERFASS,D.,A.,... - 《Microbiology》 被引量: 56发表: 1987年 Interaction of beta-lactam antibiotics with the penicillin-...
Meropenem-vaborbactam is a combination of a carbapenem with a β-lactamase inhibitor which is not a β-lactam molecule. Meropenem penetrates the cell wall of GNB. It is generally resistant to β-lactamase hydrolysis by the penicillinases and cephalosporinases produced by Gram-positiv...
Herein, we describe the development of non-β-lactam-based potentiator molecules that synergize with β-lactam antibiotics and β-lactam-β-lactamase inhibitor combinations against MDR/XDR P. aeruginosa phenotypes. In combination with <10 M of this adjuvant, aztreonam and meropenem display growth-...