Ehmann DE, Jahic H, Ross PL, Gu RF, Hu J, Kern G, Walkup GK, Fisher SL (2012) Avibactam is a covalent, reversible, non-beta- lactam beta-lactamase inhibitor. Proc Natl Acad Sci U S A 109(29):11663-11668. doi:10.1073/pnas.1205073109...
Ceftazidime/avibactam: a novel cephalosporin/nonbeta-lactam beta-lactamase inhibitor for the treatment of complicated urinary tract infections and complicated ... V Celeste,H Jose,A Nishaal - 《Drug Design Development & Therapy》 被引量: 9发表: 2016年 Ceftazidime-avibactam a novel cephalosporin/ be...
This thought led to the development of Avibactam, a Diazabicyclooctane compound, which was approved by FDA in February 2016 as the first non-lactam ß-lactamase inhibitor to be used to treat complex intra-abdominal infections in combination with ceftazidine and metrodinazole. Another chemically...
The intrinsic resistance to β-lactam antibiotics was due mainly to the presence of a chromosomally-encoded gene (blaC) in M. tuberculosis for a Class A, Ambler β-lactamase (BlaC). The BlaC enzyme has already been validated as one of the leading targets of tuberculosis therapy. In the ...
Meropenem-vaborbactam is a combination of a carbapenem with a β-lactamase inhibitor which is not a β-lactam molecule. Meropenem penetrates the cell wall of GNB. It is generally resistant to β-lactamase hydrolysis by the penicillinases and cephalosporinases produced by Gram-positiv...
Penicillin resistance in staphylococci is mediated by the production of enzyme peni- cillinase or beta-lactamase encoded by the blaZ gene. This enzyme inactivates the antibiotic by hydrolysis of the beta-lactam ring of the antibiotic [49]. Studies show that penicillinase genes can be present on...
Metronidazole, clindamycin, or beta-lactams with beta-lactamase inhibitor or carbapenems are the treatment of choice against anaerobes, while early surgical ... Sadanori,Akita - 《International Journal of Lower Extremity Wounds》 被引量: 7发表: 2015年 加载更多来源...
(*J01RA), of which almost all were a combination of 3rd generation cephalosporins with β-lactamase inhibitors. Prescribing the combinations of cephalosporin with β-lactamse inhibitor are justified in cases of ESBL producing strains ofE. coliandKlebsiellaand thus to keep carbapenems as reserve ...
beta-Lactamase production by bacteria continues to be one of the main mechanisms of bacterial resistance to beta-lactam antibiotics, and it seems likely to remain so. beta-Lactamase inhibitors provide 1 strategy to overcome this mechanism of bacterial resistance. Although 3 beta-lactamase inhibitor/an...
Herein, we describe the development of non-β-lactam-based potentiator molecules that synergize with β-lactam antibiotics and β-lactam-β-lactamase inhibitor combinations against MDR/XDR P. aeruginosa phenotypes. In combination with <10 M of this adjuvant, aztreonam and meropenem display growth-...