beta-lactamantimicrobial resistancecarbapenemaseenzyme mechanismThe beta-lactams retain a central place in the antibacterial armamentarium. In Gram-negative bacteria, beta-lactamase enzymes that hydrolyze the amide bond of the four-membered beta-lactam ring are the primary resistance mechanism, with multiple...
: any of a large class of natural and semisynthetic antibiotics (as the penicillins and cephalosporins) with a lactam ring Dictionary Entries Near beta-lactam beta interferon beta-lactam beta-lactamase See More Nearby Entries Cite this Entry Style “Beta-lactam.” Merriam-Webster.com ...
but also a variety of aerobes and anerobes, Talan et al (1999) suggest the use of a combination of a beta-lactam antibiotic and a beta-lactamase inhibitor, a second-generation cephalosporin (with activity against anerobes), or a combination with either penicillin and a first-generation cephal...
metallo-beta-lactamasesnovel beta-lactamase inhibitors-lactamase inhibitor:-lactam combinations remain one of the most successful strategies for the treatment of... DJ Payne,W Du,JH Bateson - 《Expert Opinion on Investigational Drugs》 被引量: 91发表: 2000年 β-Lactamases and β-lactamase inhibitors...
Sign up with one click: Facebook Twitter Google Share on Facebook beta-lactam antibiotic (redirected fromBeta-lactam antibiotics) Medical Encyclopedia Related to Beta-lactam antibiotics:beta-lactamase,Aminoglycosides n. Any of a class of broad-spectrum antibiotics, such as the penicillins and the ce...
Use Of Beta-Lactam/Beta-Lactamase Inhibitor Combinations To Treat Community-Acquired Respiratory Tract Infections Suwangool,Panpit.Use of [beta]-lactam/[beta]-lactamase inhibitor combinations to treat nosocomial pneumonia. The Pediatric Infectious Disease Journal . 2002... HE Akalin - 《Infectious Dise...
Piperacillin-tazobactam: a beta-lactam/beta-lactamase inhibitor combination. Piperacillin-tazobactam is a beta-lactam/beta-lactamase inhibitor combination with a broad spectrum of antibacterial activity that includes Gram-positive a... A Gin,L Dilay,JA Karlowsky,... - Expert review of anti-...
A peculiar characteristic of the beta-lactam resistance, shown by S. pneumoniae, is that the mode of resistance is an alteration in the penicillin binding proteins on the bacterial surface rather than the production of beta lactamase. This characteristic also confers resistance to multiple classes ...
A novel beta-lactamase inhibitor has been isolated from Streptomyces clavuligerus ATCC 27064 and given the name clavulanic acid. Conditions for the cultiva... C Reading,M Cole - 《Antimicrob Agents Chemother》 被引量: 1051发表: 1977年 Monotherapy versus beta-lactam-aminoglycoside combination treatment...
The resistance of bacteria to the normally lethal action of beta-lactam antibiotics is largely due to the production of beta-lactamases that catalyze the hydrolysis of the beta-lactam. One class of these enzymes is a zinc-dependent metallo-beta-lactamase for which there are no clinically available...