1. inhibitors of cell wall synthesis 2. Target of Protein Synthesis 3. Bacteria nucleic acid pathway 4. cell membrane function Name the 5 beta-lactam antibiotics 1. Penicillins 2. Cephalosporins 3. Monobactams 4. Carbapenems 5. B-Lactamase inhibitors ...
Beta-lactam elastase inhibitorsThe compounds are useful as anti-inflammatory agents, particularly in the treatment of adult respiratory distress syndrome and rheumatoid arthritis.V. John JasysMichael S. KellogRobert A. Volkmann
(penicillin G). The presence of a methoxy or hydroxymethyl group on the α face of the β-lactam ring, e.g., in cefoxitin or 6α-(hydroxymethyl)penicillanic acid, results in a displacement of the water (–712), thereby allowing the mechanism-based inhibitors to form rather stable acyl-...
Orally active beta-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones. Orally Active Beta-Lactam Inhibitors of Human-Leukocyte Elastase-1 -Activity of 3,3-Diethyl-2-Azetidinones. Shah,S.K,Dorn,C.P,Finke,P.E,Hale,J.J... SK Shah,CPD Jr,PE Finke,....
NOVEL SUCCINIC ACID METALLO-BETA-LACTAMASE INHIBITORS AND THEIR USE IN TREATING BACTERIAL INFECTIONS This invention relates to novel substituted succinic acid metallo-β-lactamase inhibitors which are useful potentiators of β-lactam antibiotics. Accordingly, the present invention provides a method of treat...
Orally Active Beta-Lactam Inhibitors of Human-Leukocyte Elastase-1 -Activity of 3,3-Diethyl-2-Azetidinones. Shah,S.K,Dorn,C.P,Finke,P.E,Hale,J.J,Hagmann,W.K,Brause,K.A,Chandler,G.O,Kissinger,A.L,Ashe,B.M,Weston,H,Knight,W.B,Maycock,A. L,Dellea,P.S,Fletcher,D.S,Hand,K....
Beta-lactamase inhibitors such as clavulanic acid, sulbactam, and tazobactam Chemical structure The beta-lactam ring is common to all BLA. In the penicillin group, the beta-lactam ring is connected to a five-member thiazolidine ring and has one side chain (R1). In cephalosporins, the beta-lac...
ChemInform Abstract: Chemistry and Synthesis of Some Novel β-Lactam Antibiotics and . beta.-Lactamase Inhibitorsorganic chemistry, reviewantibioticsChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ...
The present invention is directed to certain boron-based compounds (boronic acids and cyclic boronic acid esters) which are beta-lactamase inhibitors and antibacterial compounds. The compounds and their pharmaceutically acceptable salts are useful alone and in combination with beta-lactam antibiotics for ...
None of the beta-lactam agents alone was able to kill more than 19 of the 26 isolates. We conclude that beta-lactam agents combined with beta-lactamase inhibitors have both inhibitory and bactericidal activity against cefoxitin-resistant members of the B. fragilis group provided that the ...