opportunities afforded by new technologies such as serial femtosecond crystallography; the need for new inhibitors, particularly for MBLs; the likely impact of new beta-lactam:inhibitor combinations and the continuing clinical importance of beta-lactams mean that this remains a rewarding research area. ...
When the beta-lactam ring of this antibiotic... K Bush - 《Clinical Microbiology Reviews》 被引量: 235发表: 1988年 Class A beta-lactamases--enzyme-inhibitor interactions and resistance. Arg244 is involved in positioning beta-lactams, especially penicillins and beta-lactamase inhibitors, via their...
: any of a large class of natural and semisynthetic antibiotics (as the penicillins and cephalosporins) with a lactam ring Dictionary Entries Near beta-lactam beta interferon beta-lactam beta-lactamase See More Nearby Entries Cite this Entry Style “Beta-lactam.” Merriam-Webster.com ...
beta-lactam antibiotic (redirected fromBeta-lactam antibiotics) Medical Encyclopedia Related to Beta-lactam antibiotics:beta-lactamase,Aminoglycosides n. Any of a class of broad-spectrum antibiotics, such as the penicillins and the cephalosporins, that contain a beta-lactam ring. ...
Suwangool,Panpit.Use of [beta]-lactam/[beta]-lactamase inhibitor combinations to treat nosocomial pneumonia. The Pediatric Infectious Disease Journal . 2002... HE Akalin - 《Infectious Disease in Clinical Practice》 被引量: 7发表: 2002年 Surveillance and Detection of Inhibitor-Resistant Beta-Lacta...
The MICs for the beta-lactam beta-lactamase inhibitor combinations demonstrated resistance only to ampicillin-clavulanate, 16/8 vs. 8/4 micrograms ml-1 respectively. In contrast, there was increased susceptibility to ampicillin-sulbactam, ampicillin-tazobactam, and piperacillin-tazobactam. When compared ...
Piperacillin‐Tazobactam: A New β‐Lactam‐β‐Lactamase Inhibitor Combination We reviewed the spectrum of activity, pharmacokinetics, clinical efficacy, adverse effects, and relative advantages of piperacillin-tazobactam, a new β-la... Karen P. Daniel,Lynne C. Krop - 《Pharmacotherapy the Journal ...
例句:AmpC beta-lactamases are clinically important cephalosporinases encoded on the chromosomes of many of the Enterobacteriaceae and a few other organisms, where they mediate resistance to cephalothin, cefazolin, cefoxitin, most penicillins, and beta-lac...
anerobes, Talan et al (1999) suggest the use of a combination of a beta-lactam antibiotic and a beta-lactamase inhibitor, a second-generation cephalosporin (with activity against anerobes), or a combination with either penicillin and a first-generation cephalosporin or clindamycin and a ...
A novel beta-lactamase inhibitor has been isolated from Streptomyces clavuligerus ATCC 27064 and given the name clavulanic acid. Conditions for the cultiva... C Reading,M Cole - 《Antimicrob Agents Chemother》 被引量: 1051发表: 1977年 Monotherapy versus beta-lactam-aminoglycoside combination treatment...