β-Lactam/β-lactamase inhibitors versus carbapenems for the treatment of sepsis: systematic review and meta-analysis of randomized controlled trials. J Antimicrob Chemother 2015;70:41-7.Shiber S, Yahav D, Avni T, Leibovici L, Paul M (2015) β-Lactam/β-lactamase inhi...
The meaning of BETA-LACTAM is any of a large class of natural and semisynthetic antibiotics (as the penicillins and cephalosporins) with a lactam ring.
Penicillin, the prototype beta-lactam antibiotic, was first isolated from Penicillium notatum by Dr. Alexander Fleming in 1929. Because of difficulties in production and purification, the drug was not available for clinical use until 1941 when it was proven effective for the treatment of ...
Mutations at residue 244 (Ambler numbering system) in the class A TEM beta-lactamase confer resistance to inactivation by beta-lactamase inhibitors and result in diminished turnover of beta-lactam substrates. The Arg244Ser mutant of the OHIO-1 beta-lactamase, an SHV family enzyme, demonstrates va...
The resistance of bacteria to the normally lethal action of beta-lactam antibiotics is largely due to the production of beta-lactamases that catalyze the hydrolysis of the beta-lactam. One class of these enzymes is a zinc-dependent metallo-beta-lactamase for which there are no clinically available...
关键词: β -Lactame Mehrkomponentenreaktionen 摘要: beta -lactams are described, to be precise those of the general formula <IMAGE> in which R denotes lower alkoxycarbonyl, lower alkoxycarbonylamino, the acyl radical of an alpha - or beta -amino acid or a radical of the general formula Q...
Resistance to beta-lactam agents is due primarily to either the production of beta-lactamases or alteration inPBPs. In gram-negative organisms, beta-lactamase production is the more important resistance mechanism, whereas alteration in PBPs plays a central role inbeta-lactam resistancein clinically ...
beta-lactamase Enzyme (penicillin amido-beta-lactam hydrolase, EC 3.5.2.6, 377aa in E. coli) produced by some bacteria that makes them resistant to beta-lactam antibiotics. Competitively inhibited by clavulanic acid. Extended-spectrum beta lactamases (ESBLs) will degrade the ‘extended spectrum cep...
The pharmaceutical activity of famous antibiotics such as penicillin, cephalosporin, carbapenem, and so on containing β-lactam ring occupies 65% of the world total antibiotics market. Besides application as antibiotics, β-lactams are also in clinical use as β-lactamase inhibitor and cholesterol ...
At present, the widespread of extended-spectrum β-lactamase (ESBL)- and carbapenemase-producing organisms pose a serious challenge for clinical management and public health for their hydrolytic activity against expanded-spectrum of β-lactam antibiotics9,12,13. Hospital wastewater is a complex ...