The present invention refers to a recombinant nucleotide sequence which codes upon expression for at least a part of a hybrid beta -lactamase class A protein, wherein in that the beta -lactamase class A protein is bearing at least one heterologous sequence in a region located between two ...
英文:Metallo-beta-lactamase 中文:金属-内酰胺酶 例句:Class B metallo-β-lactamases (MBLs) have a broad substrate spectrum and can catalyze the hydrolysis of virtually all β-lactam antibiotics with the exception of monobactams. They are not ...
www.nature.com/scientificreports OPEN A new class A beta‑lactamase gene blaCAE‑1 coexists with blaAFM‑1 in a novel untypable plasmid in Comamonas aquatica Ying Li 1,2, Chengju Fang 1, Xu Wang 1, Qian Liu 3, Yichuan Qiu 1, Xiaoyi Dai 1...
Class A beta-lactamases--enzyme-inhibitor interactions and resistance. Arg244 is involved in positioning beta-lactams, especially penicillins and beta-lactamase inhibitors, via their carboxyl groups. Site-directed mutagenesis ... Y Yang,BA Rasmussen,DM Shlaes - 《Pharmacol Ther》 被引量: 146发表:...
Biochemical sequence analyses of GES-1, a novel class A extended-spectrum beta-lactamase, and the class 1 integron In52 from Klebsiella pneumoniae. Klebsiella pneumoniae ORI-1 was isolated in 1998 in France from a rectal swab of a 1-month-old girl who was previously hospitalized in Cayenne Ho...
beta-Lactamase from Bacillus licheniformis forms a stable compact intermediate state at low pH and moderate salt concentration (the A state), with properties consistent with a molten globule. A single cysteine residue was introduced into this class A beta-lactamase by site-directed mutagenesis at pos...
Negligible influence of metals on -lactamase activity ruled out that Sml-1 is a Zn2+-dependent class B beta-lactamase. Rather, sequence motifs such as SITK, YSN, and HDG forming the active core in a hypothetical structure may be typical for class C beta-lactamases. Based on the results, ...
The function of many class A enzymes can be inhibited through the use of clavulanic acid, tazobactam or sulbactam, otherwise known as classical β-lactamases inhibitors (Papp-Wallace, 2019). Unfortunately, evolved representatives of class A enzymes, such as members of the KPC and CTX-M families...
The class A β-lactamases are the largest group and have had the greatest impact clinically. They have been considered to be the earliest β-lactamases to evolve and were the chromosomal enzymes of Gram-positive bacteria. They have migrated from their original hosts on transposons and are now ...
Garau et al., “A Metallo-β-lactamase Enzyme in Action: Crystal Structures of the Monozinc Carbapenemase CphA and its Complex with Biapenem,” J. Mol. Biol. (2005) 345, 785-795. Gazouli et al., “Effect of substitution of Asn for Arg-276 in the cefotaxime-hydrolyzing class A β...