ClassificationClusterPrimary structureSubclassBeta-lactamase (EC 3.5.2.6) synthesis, particularly in Gram-negative bacilli, is a major mechanism of natural and acquired resistance to beta-lactams, sometimes accompanied by impermeability and/or active efflux. These enzymes have been classified into four ...
Most strains of P aeruginosa (as well as Enterobacter spp, Citrobacter freundii, Providencia spp, Morganella morganii, and Serratia spp) that are resistant to third-generation cephalosporins produce a functional group 1 (molecular class C) beta-lactamase. A representative of this class is the Amp...
An evolutionary classification of the metallo-beta-lactamase fold proteins. All the detectable metallo-beta-lactamase fold proteins were identified in the publicly available sequence databases and complete genome sequences using it... L Aravind - 《Silico Biol》 被引量: 331发表: 1999年 Redefining ex...
A list of attributes is also suggested for the description of a new beta-lactamase, including the requisite microbiological properties, substrate and inhibitor profiles, and molecular sequence data that provide an adequate characterization for a new beta-lactam-hydrolyzing enzyme. 展开 ...
ß-Lactamase Classification and Amino Acid Sequences for TEM, SHV and OXA Extended- Spectrum and Inhibitor Resistant Enzymes, www.lahey.org/studies (2018). 19. Woodford, N., Fagan, E. J. & Ellington, M. J. Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum (...
OBJECTIVES: To develop a rapid and reliable tool to detect by multiplex PCR assays the most frequently widespread beta-lactamase genes encoding the OXA-1-l... C Dallenne,AD Costa,D Decré,... - 《Journal of Antimicrobial Chemotherapy》 被引量: 1167发表: 2010年 ...
www.nature.com/scientificreports OPEN A new class A beta‑lactamase gene blaCAE‑1 coexists with blaAFM‑1 in a novel untypable plasmid in Comamonas aquatica Ying Li 1,2, Chengju Fang 1, Xu Wang 1, Qian Liu 3, Yichuan Qiu 1, Xiaoyi Dai 1...
More effective and safe derivatives launched.;;Classification Generation I: Cephalothin, Cephalexin Generation II: Cefuroxime, Cefamandole Generation III: Cefotaxime, Ceftazidime Generation IV: Cefpirome, Cefepime;Advantages vs. Penicillins More stable to b-lactamase Wider spectrum Stronger AB activity ...
Structure-based classification of class A beta-lactamases, an update Alain Philippon, ... Roger Labia, in Current Research in Translational Medicine, 2019 Abstract Beta-lactamase (EC 3.5.2.6) synthesis, particularly in Gram-negative bacilli, is a major mechanism of natural and acquired resistance ...
The simplest β-lactamase classification method is that of Ambler which categorized them by theiramino acidsequence. With this method, there are four classes, A–D. Class B enzymes have one or twozinc ionsat the point of catalysis whereas the other three classes have aserineresidue in the act...