Non-carbapenemUTIβ-Lactam/β-lactamase inhibitorThis systematic review was conducted to compare the efficacy of non-carbapenem 尾-lactam/尾-lactamase inhibitors (BLBLIs) versus carbapenems for the treatment of urinary tract infections (UTIs) caused by extended-spectrum 尾-lactamase-producing ...
Ceftazidime/avibactam: a novel cephalosporin/nonbeta-lactam beta-lactamase inhibitor for the treatment of complicated urinary tract infections and complicated ... V Celeste,H Jose,A Nishaal - 《Drug Design Development & Therapy》 被引量: 9发表: 2016年 Ceftazidime–avibactam: novel antimicrobial combi...
Molecular basis of the non-beta-lactamase-mediated resistance to beta-lactam antibiotics in strains of Haemophilus influenzae isolated in Canada. A study recently conducted across Canada showed that 64 of 2,503 clinical isolates of Haemophilus influenzae were resistant to beta-lactams without product.....
Despite the fact that pneumococci are naturally transformable organisms, no β-lactamase-producing strain has yet been described. A much more complex resistance mechanism has evolved in S. pneumoniae that is mediated by a sophisticated restructuring of the targets of the β-lactams, the penicillin-...
We gave intravenous infusions of sulbactam, a beta-lactamase inhibitor, in combination with ampicillin or cephalothin to women 2 days after cesarean section delivery. The elimination t1/2 was 1.0 hours, the volume of distribution at stea... G Foulds,RD Miller,AK Knirsch,... - 《Clinical Pha...
A non-beta-lactam antibiotic inhibitor for enterohemorrhagic Escherichia coli O104:H4A non-beta-lactam antibiotic inhibitor for enterohemorrhagic Escherichia coli O104:H4Dynamic simulationβ-LactamaseE. coliO104: H4Non-β-lactam inhibitorThe overuse of antibiotics has caused an increased prevalence of dr...
K. The complexed structure and antimicrobial activity of a non-beta-lactam inhibitor of AmpC beta-lactamase. Protein Sci. 1999, 8, 2330-2337.Powers, R. A.; Blazquez, J.; Weston, G. S.; Morosini, M. I.; Baquero, F.; Shoichet, B. K. The complexed structure and antimicrobial ...
coli beta-lactamase can be significantly retarded when the good substrate benzylpenicillin is also present. The development of a characteristic chromophore (lambda max 318 nm) during beta-lactamase inactivation suggests that covalent modification of the enxymes is involved; arginine and/or lysine ...
The complexed structure and antimicrobial activity of a non-beta-lactam inhibitor of AmpC beta-lactamase. Protein Sci 1999; 8: 2330-7.Powers, R.A., et al., The complexed structure and antimicrobial activity of a non-beta-lactam inhibitor of AmpC beta-lactamase. Protein Sci, 1999. 8(11)...
beta-LactamaseE. coli O104: H4Non-beta-lactam inhibitorThe overuse of antibiotics has caused an increased prevalence of drug-resistant bacteria. Bacterial resistance in E. coli is regulated via production of beta-lactam-hydrolyzing beta-lactamases enzymes. Escherichia coli O104...