The complexed structure and antimicrobial activity of a non-beta-lactam inhibitor of AmpC _beta- lactamase. Protein Sci 1999; 8 : 2330-7.Powers, R. A., Blazquez, J., Weston, G. S., Morosini, M.-I., Baquero, F., and Shoichet, B. K. (2007) The complexed structure and ...
Ceftazidime/avibactam: a novel cephalosporin/nonbeta-lactam beta-lactamase inhibitor for the treatment of complicated urinary tract infections and complicated ... V Celeste,H Jose,A Nishaal - 《Drug Design Development & Therapy》 被引量: 9发表: 2016年 Ceftazidime-avibactam a novel cephalosporin/ be...
Despite the fact that pneumococci are naturally transformable organisms, no β-lactamase-producing strain has yet been described. A much more complex resistance mechanism has evolved in S. pneumoniae that is mediated by a sophisticated restructuring of the targets of the β-lactams, the penicillin-...
coli beta-lactamase can be significantly retarded when the good substrate benzylpenicillin is also present. The development of a characteristic chromophore (lambda max 318 nm) during beta-lactamase inactivation suggests that covalent modification of the enxymes is involved; arginine and/or lysine ...
K. The complexed structure and anti- microbial activity of a non-beta-lactam inhibitor of AmpC beta- lactamase. Protein Sci. 1999, 8, 2330-2337.Powers, R. A.; Blazquez, J.; Weston, G. S.; Morosini, M. I.; Baquero, F.; et al. The complexed structure and antimicrobial activity ...
beta-lactam-beta-lactamase inhibitors (BLIs) have previously demonstrated antimicrobial activity against Acinetobacter baumannii (AB). Colistin retains the highest susceptibility rate against A. baumannii, and has demonstrated synergy with other antimicrobials, including beta-lactam-BLIs. Therefore, we ...
beta-LactamaseE. coli O104: H4Non-beta-lactam inhibitorThe overuse of antibiotics has caused an increased prevalence of drug-resistant bacteria. Bacterial resistance in E. coli is regulated via production of beta-lactam-hydrolyzing beta-lactamases enzymes. Escherichia coli O104: H4 is a multi-...
Evaluation of the in vitro efficacy of non-beta-lactam antibiotics in extended-spectrum beta-lactamase-producing and non-producing Klebsiella spp. and Escherichia coli strainsdoi:10.47582/JOMPAC.900146Gknur Yapar TorosFunda TimurkaynakJournal of Medicine and Palliative Care...
metallo-beta-lactamasevirtual drug designmolecular dynamicsimipenemaseZn-chelating inhibitorsTEMPERATURE MOLECULAR-DYNAMICSFORCE-FIELDPROTEINAntibiotic resistance (AR) remains one of the leading global health challenges, mostly implicated in disease-related deaths. The Enterobacteriaceae-producing metallo-beta-...
Beta-lactamase genes (bla) were detected in 34 (79.1%) of the isolates. The dominantblagene wasblaTEM, recovered from 33 (76.7%) of the isolates, majority being TEM-1 (24, 72.7%) followed by TEM-57, (10, 30.3%). TheblaOXA-10 andblaCTX-M-15 were detected only in a singleS....