Unfortunately, unlike penicillin, there are no validated skin testing reagents to aid in confirming the presence of specific IgE antibodies to these drugs. This review summarizes what is known about hypersensitivity reactions to non-beta lactam antibiotics, and includes practical approaches to read...
On June 23, 2022, the U.S. Food and Drug Administration (FDA) notified the pharmaceutical industry of an important update to Non-Penicillin Beta-Lactam Drugs: A CGMP Framework for Preventing Cross-Contamination, published on April 17, 2013.1This new draft guidance broadens ...
delayed drug hypersensitivitydrug provocation testnon-beta-lactam antibioticsnon-immediate reactionsnon-steroidal anti-inflammatory drugspenicillinskin testExanthemas are frequently encountered in the pediatric population and often occur while patients concomitantly receive a drug, leading to a high prevalence ...
Introduction: Beta-lactam (BL) antibiotics are the most often involved drugs in allergic reactions. Mild cutaneous reactions such as maculopapular exanthem... SS Cimen,ZH Demirkale,E Yucel,... - 《International Archives of Allergy & Immunology》 被引量: 0发表: 2023年 PD32 - Non-immediate ...
Advances in structural biology, genetics, bioinformatics, etc. resulted in the availability of an enormous pool of information enabling the analysis of the
Mtb β-lactamase (BlaC) is extremely efficient in hydrolyzing ß-lactam antibiotics which renders/leads to protection and/or resistance to this bug. There is a compelling need to develop new non-lactam inhibitors which can bind and inhibit BlaC, but cannot be hydrolyzed, thus neutralizing this...
The spectrum of anti-TB drugs consisting of non β-lactam scaffolds has been expanded by the development of new boronic acid derivatives and cationic peptidic inhibitors that proved effective in neutralizing bacterial resistance, especially when administered in combination with antibiotics. The intrinsic ...
Although the ST72-MRSA-IV isolates in the present case were susceptible to most non-β-lactam agents (Table 1), they developed reduced susceptibility to three key drugs, namely vancomycin, daptomycin, and rifampicin. The possible risk factors for the development of daptomycin nonsusceptible strains...
3f). In addition, the non-antibiotic pharmaceuticals promoted the expression of ampC (Table S24), which is related to resistance towards β-lactam antibiotics [74]. We also found that the exposure of non-antibiotic pharmaceuticals caused large-scale changes in the expression of TonB-related ...
(14.9%).Adverse cutaneous drug reactions in our study population were mainly induced by beta-lactam antibiotics and non-steroidal anti-inflammatory drugs. Th... Mahmood,Farshchian,Akram,... - 《Clinical Cosmetic & Investigational Dermatology》 被引量: 2发表: 2015年 patient during antiretroviral drug...