Assoc,Prof,IvanLambeve,mail,itlambevmail,bg,NONBETA,LACTAMANTIBIOTICS,MedicalUniversityofSofia,FacultyofMedicineDepartme
The invention provides a newly discovered oxadiazole class of antibiotics. The oxadiazoles impair cell-wall biosynthesis and exhibit activities against the Gram-positive bacteria such as the bacterium , including methicillin-resistant (MRSA) and vancomycin-resistant and linezolid-resistant . For example, ...
Nozaki Y, Katayama N, Ono H (1987) Binding of a non-β -lactam antibiotic to penicillin-binding proteins. Nature 325:179–180Nozaki, Y., N. Katayama, H. Ono, S. Tsubotani, S. Harada, H. Okazaki, and Y. Nakao. 1987. Binding of a non-beta-lactam- antibiotic to penicillin-binding...
Other than avoidance of the putative drug, management of hypersensitivity reactions to non beta-lactam antimicrobials may also include tolerance induction or desensitization [14] where no alternative antibiotics can be used and the benefits of reintroducing the drug outweigh the risks. Protocols have bee...
pneumoniae over a five-year period, and its escalating resistance to beta-lactam/beta-lactamase inhibitors and aminoglycosides that is possibly attributable to the widespread use of these antibiotics in our hospital.L C Loh... LC Loh,HK Chin,YY Chong,... - 《Singapore Med J》 被引量: 18发...
Suspected allergy to betalactam is common in children. However, the risk of anaphylaxis and fatal anaphylaxis is low, estimated at 0.015%004% and 0.0015002% of treated patients, respectively (1, 2). Up to recently, a provocation challenge was recommended in children with a suspected betalactam...
The drugs responsible for non-immediate type beta-lactam allergy were amoxicillin-clavulanate (75%), sulbactam-ampicillin (6.3%), penicillin (6.3%), ceftriaxone (6.3%), cefaclor (6.3%). The diagnosis of non-immediate type beta-lactam allergy was determined by provocation tests (n=11) prick/...
2013.1This new draft guidance broadens the scope of the previously released guidance to include all compounds containing a beta-lactam ring in their structure (including intermediates and derivatives). For manufacturers of nonantibacterial beta-lactam compounds, this guidance also pro...
Objective: Enterococcus faecalis and Enterococcus faecium are generally resistant to daptomycin and beta-lactam antibiotics. However, documented in vitro data suggests synergy between several beta-lactam antibiotics and daptomycin against resistant organisms. Primary goal of the study was to check various co...
beta-Lactamase production is the common mechanism of resistance of beta-lactam antibiotics. Knowledge of inter-residue interactions in protein structures increases our understanding of protein structure and stability. We have systematically analysed the contribution of C-H center dot center dot center dot...