aeruginosaand avibactam is a novel nonbeta-lactam beta-lactamase inhibitor. Avycaz®, the trade name for this new combination antibiotic, restores the activity of ceftazidime against some of the previously resistant pathogens. Avycaz was approved in 2015 for the treatment of complicated urinary tract...
The complexed structure and antimicrobial activity of a non-beta-lactam inhibitor of AmpC beta-lactamase. Protein Sci 1999; 8: 2330-7.Powers, R.A., et al., The complexed structure and antimicrobial activity of a non-beta-lactam inhibitor of AmpC beta-lactamase. Protein Sci, 1999. 8(11)...
Avibactam (formerly NXL104, AVE1330A) is a synthetic non-β-lactam, β-lactamase inhibitor that inhibits the activities of Ambler class A and C
Selective toxicity antibacteribiotics is considered to be due to interactions with targets either being unique to bacteria or being characterized by a dich
Antimicrobial resistance among these bacilli is increasing on a worldwide basis, especially resistance against 尾 lactam antibiotics due to the development of 尾 lactamase enzymes. Carbapenam which were considered drug of choice are now showing resistance. Thus, 尾 lactamase inhibitors should be ...
Piperacillin, beta-lactam inhibitor plus gentamicin as empirical therapy of a sequential regimen in febrile neutropenia of pediatric cancer patients The beta-lactam/beta-lactamase inhibitor combinations are a good choice for empirical antimicrobial therapy in febrile neutropenic patients, because their ......
We reveal connections between β-lactam susceptibility, peptidoglycan synthesis, and blockages in undecaprenyl phosphate metabolism. The synergy of the β-lactam/β-lactamase inhibitor combination ceftazidime/avibactam is primarily mediated by inhibition of the PenB carbapenemase. In comparison with ...
TEM-1 β-lactamase degrades β-lactam antibiotics with a strong preference for penicillins. Sequence reconstruction studies indicate that it evolved from ancestral enzymes that degraded a variety of β-lactam antibiotics with moderate efficiency. This ge
lactamase, thus restoring sulbactam activity againstAcinetobacter(El-Ghali et al.2023). Sulbactam and durlobactam were non-inferior to colistin, each given as an add-on to imipenem with cilastatin. Sulbactam and durlobactam have demonstrated good tolerability and a lower risk of nephrotoxicity ...
Antibodies against beta-lactamase can improve ceftazidime treatment of lung infection with beta-lactam-resistant Pseudomonas aeruginosa in a rat model of chronic lung infection. APMIS 110, 881–891 (2002). Article CAS PubMed Google Scholar Ciofu, O. Pseudomonas aeruginosa chromosomal beta-lactamase ...