Background/Objectives: Among various carbapenemases, New Delhi metallo-beta-lactamases (NDMs) are recognized as the most powerful type capable of hydrolyzing all beta-lactam antibiotics, often conferring multi-drug resistance to the microorganism. The objective of this review is to synthesiz...
First time in 2009, New Delhi metallo-β-lactamase-1 (NDM-1) was identified inKlebsiella pneumoniafrom a clinical sample isolated from a tourist patient in New Delhi5. Further assessments showed that this enzyme had high resistance to all classes of beta-lactam antibiotics except monobactams6. ...
New Delhi Metallo-Beta-Lactamase: Structural Insights into Beta-Lactam Recognition and Inhibition Metallo-β-Lactamases: Structural Features, Antibiotic Recognition, Inhibition, and Inhibitor Design. Wang Jing-Fang,Chou Kuo-Chen. Current Topics in ... D King,L Worrall,R Gruninger,... - 《Journal...
The New Delhi metallo-β-lactamase–1 (NDM-1) has received the most attention recently. Originally described in a K. pneumoniae isolate from India in 2008, NDM-1 enzymes have since been reported in the United States, the United Kingdom, and a number of other countries, p...
New Delhi metallo-β-lactamase Klebsiella pneumoniae Catheter-related infection Hemodialysis Introduction Expression of the β-lactamase enzymes known as carbapenemases has become widespread among clinically important Enterobacteriaceae and non-enteric gram-negative bacilli (Pseudomonas spp. and Acinetobacter bauman...
New Delhi metallo-β-lactamase (NDM) 来自 Semantic Scholar 喜欢 0 阅读量: 26 作者:Hao Yang,Michael W. Crowder 摘要: Metallo-β-lactamases (MBLs) are a class of Zn(II)-containing enzymes that hydrolyse the β-lactam bond in β-lactam-containing antibiotics, resulting in products that no ...
The emergence of carbapenemase producing bacteria, especially New Delhi metallo-β-lactamase (NDM-1) and its variants, worldwide, has raised amajor public health concern. NDM-1 hydrolyzes a wide range of β-lactam antibiotics, including carbapenems, whic
Characterization of novel plasmid-mediated β-lactamases (SHV-167 and ACT-16) associated with New Delhi metallo-β-lactamase-1 harbouring isolates from neo... Neonatal sepsis due to carbapenem-resistant bacteria is difficult to treat due to limited therapeutic options. The detection of the new car...
Discovery of potential inhibitors against New Delhi metallo-β-lactamase-1 from natural compounds: in silico-based methods Article Open access 27 January 2021 Introduction ß-lactam antibiotics are the most extensively used antimicrobial compounds worldwide and are used to treat a wide variety of ...
New Delhi Metallo-beta-Lactamase-1 (NDM-1) protein structure was extracted from the PDB (ID 4HL2) at 1.05 Å resolution. Docking was performed within a grid consisting 40 × 40 × 40 in three dimensions. The grid box was centered at the 1.291, 11.129 and 15.3 coordinates in the x, ...