METALLO-BETA-LACTAMASE INHIBITORSThe present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.ベネット,フランク...
英文:Metallo-beta-lactamase 中文:金属-内酰胺酶 例句:Class B metallo-β-lactamases (MBLs) have a broad substrate spectrum and can catalyze the hydrolysis of virtually all β-lactam antibiotics with the exception of monobactams. They are not ...
Homo-cysteinyl peptide inhibitors of the L1 metallo-beta-lactamase, and SAR as determined by combinatorial library synthesis. Homo-cysteinyl peptides were found to be more active than cysteinyl peptides toward L1 metallo-β-lactamase as reversible competitive inhibitors. A combina... S Qin,A Law...
1) and its stereoisomers were reported as broad‐spectrum inhibitors to subclass B1, B2, and B3 MBLs, especially with submicromolar potency to multiple B1 MBL enzymes (Bacillus cereus (Bcll), NDM-1 and VIM-2) [18]. The corresponding d-stereoisomer (1) is a more potent...
The long-term objective of the proposed research is the rational design and preparation of irreversible inhibitors of the Zn(II)-containing beta-lactamases. Given the apparent structural and mechanistic differences among the metallo-beta-lactamases, this objective can only be realized after detailed ...
Carbapenem Derivatives as Potential Inhibitors of Various β-Lactamases, Including Class B Metallo-β-Lactamases A variety of 1β-methylcarbapenem derivatives were screened to identify inhibitors of IMP-1 metallo-β-lactamase, a class B β-lactamase, in an automated m... Rie,Nagano,Yuka,... -...
High-resolution crystal structures of three inhibitors in complex with VIM-2 revealed hydrophobic interactions for the diethyl groups in the phosphonate ester (inhibitor 2b), the mercapto bridging the two active site zinc ions, and tight stacking of the benzene ring to the inhibitor between Phe62,...
The present invention relates to metallo-尾-lactamase inhibitor compounds of Formula I: (I) and pharmaceutically acceptable salts thereof, wherein Z, R A , X 1 , X 2 and R B are as defined herein. The present invention also relates to compositions which comprise a metallo-尾-lactamase ...
The present invention provides a inhibitor of a metallo -. Beta. - lactamase inhibitor containing a reduced form of graphene and a metallobeta lactamase inhibitor containing an oxidized graphene, wherein the size of the graphene is less than 0.1 nm and less than 500 nm.The present invention ...
The present invention relates to metallo-beta-lactamase inhibitor compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein Z, RA, X1, X 2 and R1are as defined herein. The present invention also relates to compositions which comprise a metallo-beta-lactamase inhibitor compound ...