The recombinant proteins according to the present invention are - useful for inducing clonal expansion of a B cell having a predetermined antigen-specificity without the need for T cell or CD40L mediated co-stimulation. Thus, the present invention provides tools for clonal expansion of B cells ...
CSR, SHM, and clonal expansion. This conclusion is corroborated by a parallel study independently demonstrating that engineered B cells could be used as a durable and evolving strategy to protect against HIV28. In the human setting,
如杂交瘤,记忆B细胞或者ASC(antibody-secreting cells)培养技术及基于BCR的抗原染色技术;2)在微小体积中培养的技术,如Single B cell screening methodologies,B cell replica methodologies,Single B cell repertoire analysis and clonal expansion-guided identification。
Intrathecal B-cell clonal expansion, an early sign of humoral immunity, in the cerebrospinal fluid of patients with clinically isolated syndrome suggestive of multiple sclerosis. Lab. Invest. 83, 1081–1088 (2003). Article PubMed Google Scholar Saiz, A. et al. MRI and CSF oligoclonal bands ...
The relative ability of Th1 and Th2 T cells to help B cells remains controversial as do the mechanisms by which both T cell subsets provide help in vivo. Whether this help affects the clonal expansion and/or differentiation of B cells has been difficult to assess due to the low frequency ...
(CDR3) in the four samples were different, without a specific pattern or shared CDR sequences. The extent of clonal expansion in the four samples showed that more than 80% of the clonotypes of each sample were represented by only one cell, and the clonotype with the greatest expansion ...
对三个不同的脏器的克隆扩张状态(clonal expansion status)进行分析,结果显示,纵隔淋巴结中75%以上的B细胞属于扩张克隆(expanded clonotypes),而在脾脏和肺中,这个数值不到20%(图3A)。 根据特定的克隆拥有的细胞的数目,可以把克隆分成不同的类型,例如single (1 cell), small (between 1 and 5 cells), medium...
(单细胞 + BCR测序). Surprisingly, these clonal cells had more characteristics of AT2 (alveolar epithelial cell type 2) cells than B cells; thus, these cells were named AT2-like cells. Therefore,we propose that secretion of IgA into the ECM by AT2-like cells is an important process that ...
germinal center B cell clonal expansion cyclin D3 FOXO1 c-Myc cyclin D2 B cell non-Hodgkin lymphoma B-NHL Introduction The human immune system is the warden of local and global cellular fitness, protecting the health of bodily functions. B cells act at the forefront of providing lifelong immu...
MBL分为3个亚型:①低计数MBL或克隆性B细胞扩增(expansion):克隆性CLL/SLL表型B细胞计数<0.5x109/L,且无其他B细胞增殖性疾病的诊断特征。这一阈值是基于种群(人群)中克隆B细胞和临床队列研究的比较数据。②CLL/SLL型MBL:克隆性CLL...