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这个时候,机体的免疫系统还有着一种手段,即 克隆选择 ( clonal selection )。 当B细胞完成重链与轻链的重排后,它就会在细胞表面表达BCR( B cell receptors ),每个B细胞表面约有10万个BCR分子,对于同一个B细胞来说,这个B细胞上面的所有BCR识别同一个抗原。B细胞表面的BCR会像“诱饵”一样会吸引一些能与其Fab区...
Reassessing B cell contributions in multiple sclerosis. Nat. Immunol. 19, 696–707 (2018). Article CAS PubMed Google Scholar Eggers, E. L. et al. Clonal relationships of CSF B cells in treatment-naive multiple sclerosis patients. JCI Insight 2, e92724 (2017). Article PubMed PubMed ...
The double life of a B-1 cell: self-reactivity selects for protective effector functions. Nat. Rev. Immunol. 11, 34–46 (2011). Article CAS PubMed Google Scholar Herzog, S. & Jumaa, H. Self-recognition and clonal selection: autoreactivity drives the generation of B cells. Curr. Opin...
2. R. Nakagawa et al., Permissive selection followed by affinity- based proliferation of GC light zone B cells dictates cellfate and ensures clonal breadth. Proc. Natl. Acad. Sci. U.S.A. 118, e2016425118 (2021). doi: 10.1073/pnas.2016425118; pmid: 33419925 3. D. Dominguez-Sola et ...
cellsandmemory cells. Effector cells are the relatively short-lived activated cells that defend the body in an immune response. Effector B cells are calledplasmacells and secrete antibodies, and activated T cells include cytotoxic T cells and helper T cells, which carry out cell-mediated responses...
Memory B cells are not produced when B cells are activated without T cell help. SUMMARY FIGURE Questions B cells are produced according to the principle of clonal selection. Exactly what does this mean? 2. Describe what happens during T cell-dependent activation of B cells. 3. Describe “...
The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma 喜欢 0 阅读量: 30 作者: Friedman,F D.摘要: To study the association of autoimmunity and human B cell neoplasia, we have established a model of a B cell lymphoma which expresses a pathogenic ...
[9] Mesin L , Ersching J , Victora G D . Germinal Center B Cell Dynamics[J]. Immunity, 2016. [10] Nakagawa R , Toboso-Navasa A , Schips M , et al. Permissive selection followed by affinity-based proliferation of GC light zone B cells dictates cell...