In this review, we will describe the current understanding of the role of tumour-infiltrating B lymphocytes in NSCLC, discuss their prognostic significance, their functionality within the tumour microenvironment and ultimately how we might harness B-cell biology to develop B-cell therapeutic strategies ...
Clonal selection in the germinal centre by regulated proliferation and hypermutationAnimalsMiceGerminal CenterB-LymphocytesT-Lymphocytes, Helper-InducerAntigensGenes, ReporterCell ProliferationAntibody AffinityAntigen PresentationDuring immune responses, B lymphocytes clonally expand and undergo secondary ...
W. Tertiary lymphoid structures in the pancreas promote selection of B lymphocytes in autoimmune diabetes. J. Immunol. 178, 5643–5651 (2007). Article CAS PubMed Google Scholar Penaranda, C., Tang, Q., Ruddle, N. H. & Bluestone, J. A. Prevention of diabetes by FTY720-mediated ...
Two different approaches to follow clones of B lymphocytes in a diverse preimmune repertoire reveal a new process for eliminating self-reactive cells in the periphery which depends on competition between cells with different specificities. A key feature of this censoring mechanism is the selective excl...
In addition, there is a superficial and deep perivascular infiltrate of many eosinophils, lymphocytes, mast cells, and neutrophils. The seminal work of Beutner and Jordon (Jordon et al., 1967), in which immunoglobulins and C3 were shown to be deposited along the cutaneous BMZ of BP patients,...
Lymphocytes provide both innate and adaptive immunity through the ability of their receptors to sense infections and other stressful conditions. CD8 and CD4 T cells have largely evolved to eradicate intracellular and extracellular infections, respectively, through αβT-cell receptor (TCR) -recognition ...
Longitudinal analysis of the peripheral B cell repertoire reveals unique effects of immunization with a new influenza virus strain Immunization with a new influenza virus strain (2009 pdmH1N1) induced unique effects in the peripheral B cell repertoire clonal structure, a stereotyped re... B Cortina-...
ICIs work by disrupting the cancer cells’ signals, thereby exposing the tumors’ T lymphocytes to attack (Figure 2). T lymphocytes have been the major focus of efforts to therapeutically manipulate endogenous antitumor immunity because of their functions in (1) selective peptide recognition, (2) ...
I. Antigen-driven clonal proliferation, somatic hypermutation, and selection of B lymphocytes infiltrating human ductal breast carcinomas. Cancer Res. 63, 3275–3280 (2003). CAS PubMed Google Scholar Cipponi, A. et al. Neogenesis of lymphoid structures and antibody responses occur in human ...
structure that is formed by the clonal expansion of antigen-activated B-cell blasts that have migrated to the follicles of lymph nodes. The B cells in these structures proliferate and their immunoglobulin genes undergo somatic hypermutation, before the cells leave as plasma cells or memory B cells...