A recent study pointed out a similar outcome regardless CBL value exceeding or not this arbitrary cut-off in strictly defined cases (absence of cytopenias, splenomegaly and adenopathy) of clonal B cell lymphocytosis with marginal-zone features (CBL-MZ) and confirmed the really indolent behaviour ...
CLONAL B-CELL LYMPHOCYTOSIS OF MARGINAL ZONE ORIGIN (CBL-MZ): DESCRIPTION OF MAIN CLINICAL FEATURES, DISEASE EVOLUTION AND OUTCOME IN A SERIES OF 100 PATIENTSIntroduction: CBL‐MZ has been recognized in WHO classification as a provisional entity. In the present analysis we describe CBL‐MZ ...
(3) 1 case developed diffuse large B-cell lymphoma (DLBCL) of the skin; the clonal relationship of the DLBCL with the preexisting MZ-like lymphocytosis could not be investigated due to the inability to obtain by PCR the clonotypic IGHV-IGHD-IGHJ gene rearrangement of the DLBCL, likely ...
Clonal B-cell lymphocytosis of marginal zone origin (CBL-MZ) is a recently described entity characterized by the presence of clonal B cells in the blood and/or bone marrow (BM) with morphologic and immunophenotypic features consistent with marginal zone derivation in otherwise healthy individuals. ...
Targeted Next Generation Sequencing Reveals Molecular Heterogeneity in non〤LL Clonal B〤ell Lymphocytosisclonal B‐cell lymphocytosismarginal zone lymphomanext‐generation sequencingdoi:10.1002/hon.2784Irene DefrancescoSilvia ZibelliniEmanuela BoveriMarco Frigeni...
Marti, G.E. et al. Diagnostic criteria for monoclonal B-cell lymphocytosis.Br. J. Haematol.130, 325–332 (2005). ArticleGoogle Scholar Landgren, O. et al. B-cell clones as early markers for chronic lymphocytic leukemia.N. Engl. J. Med.360, 659–667 (2009). ...
C. et al. Monoclonal B-Cell lymphocytosis and chronic lymphocytic leukemia. N. Engl. J. Med. 359, 575–583 (2008). Article CAS Google Scholar Jaiswal, S. et al. Age-related clonal hematopoiesis associated with adverse outcomes. N. Engl. J. Med. 371, 2488–2498 (2014). Article ...
Rolf Billstrm,H Johansson,B Johansson,... - 《European Journal of Haematology》 被引量: 150发表: 2010年 A long-term study of patients with chronic natural killer cell lymphocytosis. Chronic natural killer cell lymphocytosis is a persistent state of natural killer (NK) cell (CD3CD16/CD56+) ...
X-linked gene analyses have supported a polyclonal LGL lymphocytosis in this syndrome. Further studies are needed to determine whether clonal progression can occur in these patients. 展开 关键词: Humans Lymphocyte Subsets T-Lymphocytes Lymphoproliferative Disorders Leukocyte Count Leukemia, Prolymphocytic, ...
[88]. However, scRNA-seq analysis has suggested that the dysfunctional state of T cells may already be present at the precursor phase of CLL, known as monoclonal B-cell lymphocytosis [86], indicating the need for early induction of immunotherapy during CLL progression. Also, pediatric leukemias...