Monoclonal B cell lymphocytosis (MBL) is both a marker of immune senescence and a potential precursor of B cell malignancy. Most MBL populations have a chronic lymphocytic leukemia-like (CLL-like) immunophenotype, but those that are CD5-negative (non-CLL-like) are also recognized and may ...
79,84 It is postulated that immunocompromised patients manifest with an abnormal response to the Epstein–Barr virus (EBV) through development of a monoclonal B cell proliferation.85 Ocular lymphoma and PCNSL are restricted to the central nervous system and are not a consequence of metastasis of ...
Monoclonal B-cell lymphocytosis in first-degree rela- tives of patients with sporadic (non-familial) chronic lymphocytic leukaemia. Br J Haematol. 2009;147(3):339-46.Matos DM, Ismael SJ, Scrideli CA, et al. Monoclonal B-cell lymphocytosis in first-degree relatives of patients with sporadic ...
High-count Monoclonal Lymphocytosis Linked to Higher Risk for Non-hematologic CancerLourdes Briz
Delphine, CasabonneJulia, AlmeidaWendy, G. NietoAlfonso, RomeroPaulino, FernándezNavarroArancha, RodriguezCaballeroSantiago, MuñozCriadoMarcos, González DíazYolanda, BenaventeSilvia, de Sanjosé
Here we describe a comprehensive evaluation of the genomic landscape of 452 CLL cases and 54 patients with monoclonal B-lymphocytosis, a precursor disorder. We extend the number of CLL driver alterations, including changes in ZNF292, ZMYM3, ARID1A and PTPN11. We also identify novel recurrent ...
Solomon BM, Chaffee KG, Moreira J, Schwager SM, Cerhan JR, Call TG, et al. Risk of non-hematologic cancer in individuals with high-count monoclonal B-cell lymphocytosis. Leukemia 2016;30:331-6.Solomon BM, Chaffee KG, Moreira J, et al. Risk of non-hematologic cancer in individuals with...
Vemurafenib was withdrawn after approximately one year of therapy, and subsequently, his peripheral lymphocytosis resolved and CLL regressed. Nevertheless, a monoclonal B cell population persisted even 732 days after discontinuation of vemurafenib.Catherine J....
5 , 6 In 2015, Puente and colleagues identified recurrent 'non-coding' mutations clustered to the 3′-UTR of NOTCH1 in 2% (11/506) previously untreated patients with CLL or monoclonal B-cell lymphocytosis. 7 The presence of these 3′-UTR mutations cause a novel splicing event, ...
Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia. Blood Am. J. Hematol. 2013, 122, 1891–1899. [Google Scholar] [CrossRef] [Green Version] Lin, X.; Wang, Z.; Wang, Y.; Feng, W. Serum MicroRNA-370 as a...