Clonal selection is a process proposed to explain how a single B or T cell that recognizes an antigen that enters the body is selected from the pre-existing cell pool of differing antigen specificities and then reproduced to generate a clonal cell population that eliminates the antigen.Latest...
Malherbe L , Hausl C , Teyton L , McHeyzer-Williams MG ( 2004 ) Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties . Immunity 21 : 669 – 679Malherbe, L., C. Hausl, L. Teyton, and M. G. McHeyzer-Williams...
Affinity gaps among B cells in germinal centers drive the selection of MPER precursors Article Open access 30 May 2024 Human germinal centres engage memory and naive B cells after influenza vaccination Article 31 August 2020 Engaging an HIV vaccine target through the acquisition of low B cel...
Potent immunoglobulins are discovered in this model via clonal selection and affinity maturation. Surviving cells acquire lasting immunity against subsequent infection by the same virus strain. As a second line of defense cells develop apoptosis-like behavior by reducing their lifetimes to eliminate ...
We applied an evolutionary genomics approach (dN/dS ratio) to evaluate the clonal selection patterns of tumors with distinct immunogram subtypes. Results We defined four major CI cycle patterns across 32 cancer types using a cancer immunogram approach. Immunogram-I was characterized by ‘hot’ ...
It is one of the most common mutations in AA patients and is associated with a positive response to IST. ASXL1 and DNMT3A mutations are common in both AA and AML/MDS. The DNMT3A mutation results in the accumulation of cells in the bone marrow due to impaired differentiation [19], while...
(Burkitt lymphoma-like phenotype); (B) flow cytometric analysis showing clonal infiltration of BM and CSF (malignant lymphoma cells in red, non-B cells in blue); (C) timeline of various therapy administrations and laboratory examinations (time corresponds with sampling, asterisk marks test ...
This observation advocates that elimination of the TP53-wt population represents a key factor in the clonal selection of TP53-deficient cells, as was also shown in the remission samples. Regarding response duration, the situation is more complex, as, on the one hand, patients reaching CR have ...
research suggests that it may be a functional HDL receptor. In addition, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with the SR-BII isoform mediating selective transfer of lipid between HDL and cells. The relative expression and functional activities of these ...
In summary, BCRs diversify predominantly in the lymph nodes and only a small selection of B cells expressing these clonal BCR variants are able to perform immunosurveillance across other sites or are temporally persistent. Higher-centrality BCRs are more likely to be seen across a larger number ...