Affinity maturation of antibodies is achieved by antigen selection of specific B lymphocyte clones expressing membrane immunoglobulin (mIg). A model system was generated to examine antigen:mIg interactions by expressing mIg specific for a hapten, phosphocholine (PC). The murine B lymphoma M12.4 was ...
Willcox1 gd T cells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human Vd2neg T cells, implicated in responses to viral infection and cancer. ...
a, Gene-level selection in point mutations measured using dN/dS ratios comparing truncal and subclonal mutations in LUAD and LUSC with 95% CIs for dN/dS ratios for 358 tumours. Error bars indicate 95% CIs. dN/dS values below 0.5 and associated with 95% CIs overlapping 1 are limited to...
Clonal evolution in cancer is intimately linked to the concept of intratumor cellular diversity, as the latter is a prerequisite for Darwinian selection at the micro-level. It has been frequently suggested in the literature that clonal evolution can be promoted by an elevated rate of mutation in ...
The second part features discussion and review papers on a diverse array of subjects, ranging from developmental considerations of clonality, principles of selection and evolution in clonal plants, a survey of clonality in algae, to potential implications of clonality for plant mating, and beyond. ...
Cuscuta australis is a common parasi... He, Jianxiao,Xiao, Yongkang,Yimingniyazi, Amanula - Biology (2079-7737) 被引量: 0发表: 2024年 Research Advance on Band Selection-Based Dimension Reduction of Hyperspectral Remote Sensing Images The typical characteristics of hyperspectral remote sensing data...
Breeding Methods for Asexually Propagated Crops and Clonal Selection ApomixesJadhav Shrinivas Shripati
47 Moreover, long-term IL-1β exposure was implicated in Cebpa–/– HSPCs (mainly MPP3) selection via activation of a self-renewal over a myeloid differentiation gene program.48 Herein, we show that although continuous IL-1α exposure had no effect on WT or Tet2+/− HSPC apoptosis, it...
Fig. 3: Clonal selection occurs during serial transplantation. a Barcoded B-ALL cells were consecutively transplanted through three generations of mice. Clonal abundance was assessed in each recipient. b K-means clustering separated leukemia clones into diminishing and expanding groups. Each section in...
Somatic genetic drift during clonal propagation leads to the emergence of genetically unique modules that constitute an elementary level of selection and individuality in long-lived clonal species. This is a preview of subscription content, access via your institution Access options Access Nature and ...