Theileria annulata: altered gene expression and clonal selection during continuous in vitro culture. Exp. Parasitol. 83:125- 133.Sutherland I.A., Shields B.R., Jackson L., Brown D.J., Brown C.G.D., Preston P.M., Theileria annulata: Altered gene expression and clonal selection during ...
This pattern of clonal evolution was only found in patients with relapse and not with refractory disease, which supports the hypothesis that clonal selection through midostaurin inhibition only occurs after a prolonged exposure. As many patients in the RATIFY and AMLSG 16-10 trials stopped or ...
Notably, the start codon of the puromycin resistance gene is placed on the “Front” expression vector, ensuring that only cells with in-frame- and targeted-integration survive the selection procedure. Additionally, all cells with off-target integration of the expression plasmids do not lose the ...
Zhu from the Microarray Core at UT Southwestern Medical Center in Dallas, TX for their expert help with ROI selection on the GeoMx DSP and data generation; and J. Villanueva, R. Inga and L. Li from the Herlyn laboratory at the Wistar Institute for their assistance with identifying and ...
Understanding the alterations that occur within the leukemia composition after therapy was of vital importance, especially at the cellular level. The clonal expansion and selection, genetic mutation, and accumulation are inherently linked to resistance, owing to the selective pressure exerted by therapy ...
aKnight and Timmis (2002) proposed a Multi-layered Artificial Immune Systems (MLAIS) that is inspired by the clonal selection theory and incorporates a feedback mechanism much like the co-stimulation in the immune network theory. 由无性系的选择理论在免疫网络理论上启发并且合并反馈机制很象co刺激的...
The first stage decision corresponds to the selection of order type, design, and production-level decisions. The variables representing the supply and demand nodes define the second stage network-flow problem. 6 The studies related to the modeling of the problem that determine the optimal point of...
As first proposed byNowell (1976), theclonal evolutionmodel for tumor progression suggests that within a population of tumor cells, a natural selection occurs that favors cells that have acquired (e.g., through additional mutations) the most aggressive phenotype. The model suggests that cancers ari...
biroi arises through reduced recombination during meiosis, via selection against homozygous individuals, or both, as is the case in Cape honeybees [25]. Minimizing LOH allows asexual species with complementary sex determination to avoid the production of diploid males. Intriguingly, however, C. biroi...
only if the model evidence for the clonal model is at least four times that of the artifact model (Supplementary Information Methods, section 2.4, and Extended Data Fig.2c,d). Fit variants thus selected are taken through to clonal structure model selection and fitness inference as described ...