Mutations in these five genes accounted for 77% of identified CHIP mutations in aplastic anemia, and the underrepresentation of TET2, JAK2, and TP53 suggests a different mechanism of clonal selection occurs in an aplastic bone marrow microenvironment. Serial sampling revealed that BCOR, BCORL1, and...
We describe a form of selection unique to clonal organisms, genotypic selection, that can result in evolution. Genotypic selection occurs when genotypically based traits are associated with differences in the rate of ramet production. It can lead to evolutionary change in quantitative trait means ...
The evolutionary timing of the observed positive selection depended on the histology for a number of genes. In LUAD, significant truncal but not subclonal selection ofB2Mpoint mutations was observed, whereas in LUSC, there was evidence for significant subclonal but not truncal selection (Fig.3a)...
As first proposed by Nowell (1976), the clonal evolution model for tumor progression suggests that within a population of tumor cells, a natural selection occurs that favors cells that have acquired (e.g., through additional mutations) the most aggressive phenotype. The model suggests that cancers...
Understanding when clonotypic focusing occurs in life is clearly important, including in neonates, when conventional adaptive immunity is less potent and gd T-cell responses may play an important role31,32. Further studies are required to more comprehrensively explore Vd1 repertoire focusing ...
Understanding the alterations that occur within the leukemia composition after therapy was of vital importance, especially at the cellular level. The clonal expansion and selection, genetic mutation, and accumulation are inherently linked to resistance, owing to the selective pressure exerted by therapy ...
Clonal Hematopoiesis of Indeterminate Potential (CHIP) occurs when hematopoietic stem cells in bone marrow undergo somatic mutations and yield genetically distinct leukocyte subpopulations with increased expression of inflammatory genes ... KM Hayden,XI Leng,JAE Manson,... - 《Alzheimers & Dementia》 被...
It is commonly thought that sexual reproduction is evolutionary reproductive mode [1], and that clonal reproduction occurs because of obstacles to sexual reproduction caused by genetic or environmental factors [4,12,14,30,31,32,33], such as male sterility [34], mate limitation [35,36], low ...
When cloning trees of various ages, it is important to determine first which part of the individual contains the most responsive cells and at what time of the year these cells are in the most responsive state. This allows selection of the most useful explants. In hardwood trees and a few ...
Most clonal expansion occurs in HSCs; TET2MUT clones also have a myeloid bias • HSCs from CH samples show increased inflammation and aging-related gene expression • These deleterious effects are attenuated in DNMT3AMUT and TET2MUT HSCs Summary Clonal hematopoiesis (CH) arises when hematopoietic...