Related to clonal:clonal expansion,Clonal selection,Clonal anergy (klōn) n. 1.A group of cells or organisms that are descended from and genetically identical to a single progenitor, such as a bacterial colony whose members arose from a single original cell. ...
2e). Consistent with our finding, a phase II study of chronic lymphocytic leukemia reported that the BTK-binding molecule, Ibrutinib, caused an efflux of tumor cells from the tissue compartments into the blood44. Clonal selection occurs during serial transplantation The spatially confined clonal ...
Somatic mutations acquired in long-lived stem cells may provide a substrate for clonal selection, resulting in somatic mosaicism.1,2 With aging, somatic mosaicism becomes common in phenotypically normal human tissues,3,4,5,6,7,8,9,10,11,12 including the blood, where it is termed clonal hemat...
We conclude that clonal replacement is the result of polyclonal invasion of GCs in which founder clones are still actively undergoing positive selection. Once invader clones enter a GC, they closely resemble founders, both transcriptionally and in their ability to undergo positive selection for clonal...
Clonal evolution begins before the development of neoplasia in IBD, accelerated by repeated cycles of epithelial wounding and repair. Here, the authors summarize the biological drivers of mutant clone selection in IBD and discuss how an evolutionary pers
One possible explanation is that parasite population structure in the Pacific region is also shaped by geographic restriction of compatible vectors. For example, parasites from Col-1 subpopulation may be adapted to An. darlingi in Chocó, since this vector had not been registered in the other ...
Our proposed model incorporates binary decision variables in the first stage decision process, which is the generalization of the work done by Wallace. The first stage decision corresponds to the selection of order type, design, and production-level decisions. The variables representing the supply ...
Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with somatic mutations that is associated with an increased risk of haematological malignancies, cardiovascular disease and all-cause mortality. CH may be caused by point mutati
Clonal evolution begins before the development of neoplasia in IBD, accelerated by repeated cycles of epithelial wounding and repair. Here, the authors summarize the biological drivers of mutant clone selection in IBD and discuss how an evolutionary pers
grade group 2 on the medial side of the main tumour focus (section H1_4) and a region described as ‘transition state’ by consensus pathology at the upper mid-edge (section H2_5). These conserved siCNV features in distinct spatial locations are noteworthy. A possible explanation is that...