Clonal evolution in cancer is intimately linked to the concept of intratumor cellular diversity, as the latter is a prerequisite for Darwinian selection at the micro-level. It has been frequently suggested in the literature that clonal evolution can be promoted by an elevated rate of mutation in ...
a, Gene-level selection in point mutations measured using dN/dS ratios comparing truncal and subclonal mutations in LUAD and LUSC with 95% CIs for dN/dS ratios for 358 tumours. Error bars indicate 95% CIs. dN/dS values below 0.5 and associated with 95% CIs overlapping 1 are limited to...
Only a fraction of subclones survives oncogene withdrawal and persists in residual tumors. The minimal residual disease phase itself is accompanied by a continued attrition of clones, suggesting an ongoing process of selection during dormancy. The reactivation of dormant residual cells into recurrent ...
As the diversity of single-cell technology proliferated, the simultaneous conduction of multiple omics at the single-cell level (single-cell multiomics) came to the front, enabling a more precise definition of cellular characterization and comprehensive exploration of transcriptional regulatory mechanisms [...
consideration when selectingtransgenic plantsin the field, in this way, a selection scheme for sugarcane transgenic plants is propose infigure 2. This approach has the advantages that notice in primarytransgenicplants any eventualsomaclonal variationcombined with the phenotypic expression of the foreign ...
In addition to a high C:N ratio, Fig.7shows that EBD also had a lower pH than the other samples. This is consistent with Soilscapes’ definition of this area as having ‘slowly permeable seasonally wet acid loamy and clayey soils’, with low fertility and impeded drainage (UK Soil Obser...
a selection process enriches for cells with proviruses integrated in genes associated with cell growth regulation. The dynamic nature of populations of cells infected with HIV during cART is not well understood, but is likely to have a profound influence on the composition of the HIV reservoir wit...
large than small clone CH. At the whole-genome level, we estimated the genetic correlation (rg) betweenDNMT3A-CH andTET2-CH as −0.48 (s.e. = 0.33,P = 0.15) and large and small clone CH as 0.37 (s.e. = 0.18,P = 0.018) using high-definition likelihood ...
Thus, the information derived from sequence-based BAC contiging is the same as for conventional approaches (i.e. contig+BAC address). It is observed that for individual clone fingerprinting approaches, the BAC address will be known by definition. ...
into said animal; and (h) isolating said transformed Mycobacterium cells from non transformed Mycobacterium cells by growing said electroporated culture in the presence of a substance which said selection marker permits transformed Mycobacterium cells but not nontransformed Mycobacteriums cells to survive...