The past several decades have given rise to more insights into the role of astrocytes in normal brain function and diseases. Astrocytes elicit an effect which may be neuroprotective or deleterious in the process of Alzheimer’s disease (AD). Impairments in astrocytes and their other functions, as...
Alzheimer’s disease (AD) is defined by the widespread accumulation of amyloid-β (Aβ) plaques and phospho-tau (pTau) neurofibrillary tangles (NFTs) throughout the brain, with the latter following a stereotypical hierarchical spatiotemporal pattern along neural networks. These AD neuropathological...
摘要: The past several decades have given rise to more insights into the role of astrocytes in normal brain function and diseases. Astrocytes elicit an effect which may be neuroprotective or deleterious in关键词:Astrocyte Alzheimer’s disease Pathogenesis ...
SenescenceSenolyticsSenescent astrocytes lose neuron-supportive function.Senescent astrocytes and other CNS cell types increase in Alzheimer's disease (AD).Targeting senescence in these cell types has reversed pathology in AD mouse models.Many drugs that modulate or clear senescence have been tested in ...
Alzheimer’s disease genetic risk is enriched in glial genes. Here, the authors derive cell-type-specific polygenic risk scores and link astrocytic genes with Aβ, and microglial genes with Aβ, tau, microglial activation, and cognitive decline. Hyun-Sik Yang , Ling Teng & Reisa A. Sperling...
To date, Alzheimer disease(AD), with the main clinical manifestations of progressive decline of cognitive and memory function, is the most common neurodegenerative disease, whose onset and development are closely associated with many factors including astrocytes. In recent years, many researches have in...
This study investigates NADPH oxidase 4 (NOX4) involvement in iron-mediated astrocyte cell death in Alzheimer’s Disease (AD) using single-cell sequencing data and transcriptomes. We analyzed AD single-cell RNA sequencing data, identified astrocyte marke
To better define roles that astrocytes and microglia play in Alzheimer’s disease (AD), we used single-nuclei RNA-sequencing to comprehensively charac
Astrocyte reactivity is an early feature of Alzheimer’s disease (AD), potentially providing a target for preclinical diagnosis and treatment[11]. Astrocytes are activated by numerous environmental stimuli[12, 13]. Reactive astrocytes are thought to be characterized by elevated expression of glial ...
Rabah et al. elegantly show that, inDrosophila, astrocytes signal to neurons with hydrogen peroxide to encode memories. This redox-based communication is disrupted by amyloid-β, a mechanism that potentially underlies cognitive deficits in Alzheimer’s disease. ...