Stratification of astrocytes in healthy and diseased brain. Brain Pathol 27, 629–644 (2017). Article CAS PubMed PubMed Central Google Scholar Messing, A., Brenner, M., Feany, M. B., Nedergaard, M. & Goldman, J. E. Alexander disease. J. Neurosci. 32, 5017–5023 (2012). Article...
[26,27]. In different circumstances, the role of astroglial cells is of paramount importance because of their strong relationship with the retinal vasculature. Astrocytes provide neurotrophic and mechanical support for both healthy and degenerating axons, but their main activity is the maintenance of ...
Astrocytes are the most abundant type of glial cell and regulate a wide range of functions in the healthy brain including maintaining optimal ion and neurotransmitter concentrations in the extracellular space, promoting neural and synapse development, and facilitating neuronal metabolism1. In some cases,...
Astrocytes are the most abundant non-neuronal cell type in the central nervous system (CNS). They serve numerous critical functions in the brain, including regulation of synapse formation and pruning, as well as regulation of neuroinflammation and lactate and glutamate levels in the brain [1]. As...
The control of cerebral vessel diameter is of fundamental importance in maintaining healthy brain function because it is critical to match cerebral blood flow (CBF) to the metabolic demand of active neurons. Recent studies have shown that astrocytes are critical players in the regulation of cerebral...
The community-based longitudinal cohort Greater-Bay-Area Healthy Aging Brain Study (GHABS) [45](clinicaltrials.gov ID: NCT06183658) was approved by the Shenzhen Bay Laboratory and collaborated hospitals’ Ethical Committees, and was launched in May 2021. The written informed consent of the GHABS...
Fig. 9. Photomicrographs of changes in GFAP expression in vivo in healthy tissue (a), reactive astrocytes in the lesion penumbra (b) and the glial scar region(c). (Figure from Sofroniew [29]). A drawback of astrocyte only cell cultures is the absence of the other glial cell types, mo...
Dysfunctions of network activity and functional connectivity (FC) represent early events in Alzheimer’s disease (AD), but the underlying mechanisms remain unclear. Astrocytes regulate local neuronal activity in the healthy brain, but their involvement in early network hyperactivity in AD is unknown. ...
Brain iron dysregulation associated with aging is closely related to motor and cognitive impairments in neurodegenerative diseases. The regulation of iron traffic at the blood-brain barrier (BBB) is crucial to maintain brain iron homeostasis. However, th
Inducible ablation of astrocytes shows that these cells are required for neuronal survival in the adult brain Glia, 34 (4) (2001), pp. 272-282 Google Scholar [15] R. Niranjan The role of inflammatory and oxidative stress mechanisms in the pathogenesis of Parkinson's disease: focus on astrocy...