It describes astrocytes as 'contextual gates' that shape neural circuitry in an adaptive, state-dependent fashion. This paradigm provides fresh perspectives on principles of astrocyte signaling and its relevance to brain function, which could spur new experimental avenues, including in computational space...
Given recent research, it is likely that the different responses of astrocytes in neurodegenerative diseases arise, in part, from differential epigenetic regulation of various functions. However, the examination of the epigenetic regulation of astrocyte function has not been reviewed, including the ...
A large body of evidence already shows that these networks are involved in neuronal modulation and play important roles in brain functions3,7–9. To date, only few imaging markers of astrocytes such as positron emission tomography (PET) probes10, pas- sive fluorescent dyes11 and genetically ...
In recent years, the roles of astrocytes of the central nervous system in brain function and neurological disease have drawn increasing attention. As a member of the N-myc downstream-regulated gene (NDRG) family, NDRG2 is principally expressed in astrocytes of the central nervous system. NDRG2...
A large body of evidence already shows that these networks are involved in neuronal modulation and play important roles in brain functions3,7–9. To date, only few imaging markers of astrocytes such as positron emission tomography (PET) probes10, pas- sive fluorescent dyes11 and genetically ...
Astrocyte: Astrocyte is a dominant glial cell in the brain found around cerebral microvessels. Astrocytes maintain neuronal function and control blood-brain barrier function via various astrocyte-derived factors and astrocytic terminal processes termed end-feet. ● Blood-brain barrier (BBB): The BBB ...
BackgroundMANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. MANF and its structural homolog CDNF, each contain an N-terminal saposin-like lipid bi...
This study in fruit flies points to brain metabolism as a cause for this and shows that a network of glial cells interacting with neurons links brain function with the need for rest and sleep. Andres Flores-Valle Ivan Vishniakou Johannes D. Seelig ResearchOpen Access21 Apr 2025 Nature ...
This Review focuses on the role of astrocytes in disorders including Alzheimer disease, Parkinson disease, Huntington disease and amyotrophic lateral sclerosis. The important roles astrocytes have in supporting neuronal function in the healthy brain are considered, along with studies that have demonstrated...
function, leading to a decreased number of synapses with only weak signals and, finally, neurodegeneration [23]. This kind of reactive astrocytes seems to be abundant in post-mortem AD brain. In mouse primary hippocampal cultures, astrocytes internalized oligomeric tau, which was followed by ...