Only two of the 15 chemical agents are definitively not alkylating agents. The rat model is thought to be of possible relevance to humans suggesting that exposure to alkylating chemicals should be considered in epidemiology studies on GBM and other brain tumors....
The alkylating agent temozolomide (TMZ) is the preferred drug for the treatment of glioblastoma (GBM). Long-term administration of TMZ induces protective autophagy in GBM cells and is associated with drug resistance. The tumor-killing effect of TMZ can be enhanced by promoting or inhibiting autopha...
The first study to reveal the binding modes of a range of inhibitors in the active site of PI3Kγ, providing a basis for the development of isoform-specific PI3K inhibitors. Article CAS PubMed Google Scholar Berndt, A. et al. The p110delta structure: mechanisms for selectivity and potency...
Chemical mutagens that mimic the naturally occurring bases are called a. nitrogen mustards. b. alkylating agents. c. base analogs. d. nitrous oxide. Do soaps and cleaners tend to be acidic or basic? 1. What pH is considered the most acidic? 2. What pH is considered the most basic? 3...
3.2.3. PI3 kinase inhibitors PI3K inhibitors target the p110 catalytic subunit of PI3K, and may be divided into two groups, isoform-specific inhibitors or pan-PI3K inhibitors; the latter can inhibit all class IA PI3Ks. In this way, they block the signal transduction through the PI3K/AKT/...
Access to services remains limited, even in developed countries with specific health networks [13, 27] and to the best of our knowledge, no action plan has been published to develop the field of oncofertility in low and middle- income countries. Table 4 Evaluation of existing models- Knowledge...
To further explore this specific interaction of YAP2L isoforms, we analyze the sequence of these three isoforms and found that there is one cysteine residue in YAP2L which is not present in YAP1 and YAP2 (Fig. 1A). Next, to explore the possibility of involvement of this cysteine residue ...
Reaction of antimalarial endoperoxides with specific parasite proteins Antimicrob. Agents Chemother., 38 (1994), pp. 1854-1858 View in ScopusGoogle Scholar 40 A Robert, J Cazelles, B Meunier Characterisation of the alkylation product of heme by the antimalarial drug artemisinin Angew. Chem. Int....
Roos WP, Kaina B . DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis.Cancer Lett2013;332: 237–248. CASPubMedGoogle Scholar Basu A, Krishnamurthy S . Cellular responses to cisplatin-induced DNA damage.J Nucleic Acids2010;2010: 201367. ...
Contradictory reports have described it either as nonspecifically reduced in cells, or else as a highly specific substrate for thioredoxin reductase (TrxR). Here we show that 1,2-dithiolane probes, such as "TRFS" probes, are nonspecifically reduced by thiol reductants and redox-active proteins,...