Management of early stages of Hodgkin''s disease requires development of treatment programs that are nominally toxic, with a low likelihood of sterility and secondary malignancies, both associated with alkylating agents. Although patients with laparotomy-staged disease without B symptoms or large ...
Chemical mutagens that mimic the naturally occurring bases are called a. nitrogen mustards. b. alkylating agents. c. base analogs. d. nitrous oxide. Do soaps and cleaners tend to be acidic or basic? 1. What pH is considered the most acidic? 2. What pH is considered the most basic? 3...
The alkylating agent temozolomide (TMZ) is the preferred drug for the treatment of glioblastoma (GBM). Long-term administration of TMZ induces protective autophagy in GBM cells and is associated with drug resistance. The tumor-killing effect of TMZ can be enhanced by promoting or inhibiting autopha...
Numerous factors contribute to cancer prevalence, including high rates of tobacco consumption, occupational exposure to specific chemicals, infectious agents like HPV and hepatitis B/C, exposure to environmental toxins, and limited access to healthcare facilities, particularly in rural areas (Table1). B...
1.4. Risk of infections due to specific chemotherapy agents Alkylating agents and Anthracyclines Anthracyclines (idarubicin, daunorubicin, and doxorubicin) are unique among chemotherapeutic drugs in that they induce apoptosis of hematopoietic cell lines (124) in the Infections in Leukemia 343 G0-G1 ...
It has subsequently been found through surface comparison of x-ray derived crystal structures of both active and inactive forms of specific kinases, that the assembly of a hydrophobic spine through sidechain interaction of discontiguous amino acids within the N-lobe, C-lobe and activation loop ...
DNA interstrand cross-links (ICLs) are complex DNA lesions generated by bifunctional alkylating agents, a class of compounds extensively used in cancer che... H Zheng,W Xin,RJ Legerski,... - 《Dna Repair》 被引量: 103发表: 2006年 加载更多来源...
Roos WP, Kaina B . DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis.Cancer Lett2013;332: 237–248. CASPubMedGoogle Scholar Basu A, Krishnamurthy S . Cellular responses to cisplatin-induced DNA damage.J Nucleic Acids2010;2010: 201367. ...
Contradictory reports have described it either as nonspecifically reduced in cells, or else as a highly specific substrate for thioredoxin reductase (TrxR). Here we show that 1,2-dithiolane probes, such as "TRFS" probes, are nonspecifically reduced by thiol reductants and redox-active proteins,...
Doll and Peto [20], compared cancer rates of specific organs in humans in the United States to cancer rates in these organs in other countries. They concluded that 75 - 80% of the cases of cancer in the United States were likely avoidable, and were due to DNA damaging agents found in ...