Only two of the 15 chemical agents are definitively not alkylating agents. The rat model is thought to be of possible relevance to humans suggesting that exposure to alkylating chemicals should be considered in epidemiology studies on GBM and other brain tumors.Carr J. Smith...
Ethidium bromide, which intercalates between base pairs in DNA, inducescytoplasmic respiratory “petite” mutations in yeast in the absenceof growth (Slonimiski et al., 1968). This effect is specific for this intercalating agent and results in a shortening of mitochondrial DNA (Goldring et al....
1.4. Risk of infections due to specific chemotherapy agents Alkylating agents and Anthracyclines Anthracyclines (idarubicin, daunorubicin, and doxorubicin) are unique among chemotherapeutic drugs in that they induce apoptosis of hematopoietic cell lines (124) in the Infections in Leukemia 343 G0-G1 ...
Forty to sixty percent of conventionally (CON) raised BALB/cAnPt (BALB/c) mice develop plasmacytomas (PCT) when injected with three 0.5 ml i.p. injections of pristane. When CON-BALB/c mice were converted to specific pathogen free (SPF) status by foster nursing caesarean delivered term mice...
It has subsequently been found through surface comparison of x-ray derived crystal structures of both active and inactive forms of specific kinases, that the assembly of a hydrophobic spine through sidechain interaction of discontiguous amino acids within the N-lobe, C-lobe and activation loop ...
The first study to reveal the binding modes of a range of inhibitors in the active site of PI3Kγ, providing a basis for the development of isoform-specific PI3K inhibitors. Article CAS PubMed Google Scholar Berndt, A. et al. The p110delta structure: mechanisms for selectivity and potency...
Together these results support the hypothesis that the mammary gland of immature rats is more susceptible to the carcinogenic, lethal, and mutagenic effects of alkylating agents represented by NMU in a carcinogen-class-specific manner. Further, the results suggest the importance of mechanistic and ...
To further explore this specific interaction of YAP2L isoforms, we analyze the sequence of these three isoforms and found that there is one cysteine residue in YAP2L which is not present in YAP1 and YAP2 (Fig. 1A). Next, to explore the possibility of involvement of this cysteine residue ...
Doll and Peto [20], compared cancer rates of specific organs in humans in the United States to cancer rates in these organs in other countries. They concluded that 75 - 80% of the cases of cancer in the United States were likely avoidable, and were due to DNA damaging agents found in ...
Specific compounds of the invention are the following:“About” is intended to mean more or less 10%, preferably more or less 5%.When R4 is selected in such a way that it is a group, in particular a lipid group, allowing the formation of nanoparticles, micelles or liposomes, the present...