MURAI J,POMMIER Y,Classification of PARP inhibitors based on PARP trapping and catalytic inhibition,and rationale for combinations with topoisomeraseⅠinhibitors and alkylating agents[M].Switzerland:Springer International Publishing,2015:261-274.Murai J, Pommier Y (2015) Classification of PARP Inhibitors ...
Antifolates –Chemicals that inhibit the activity of folic acid (vitamin B9), which is required for the formation of DNA and the growth of cells. Types of Chemotherapy Alkylating Agents The resting phase of the cell is when alkylating chemicals are most active. These medications have no effect ...
There are two types for t-AML depending on the type of mutagenic treatment and the mechanism associated with leukemogenesis [38]. Exposure to alkylating agents and/or, radiation leads to DNA-crosslinking causing unbalanced cytogenetic abnormalities, such as loss of all (or parts of) chromosomes ...
Alkalinizing Agents (info) Alkylating Drugs (info) Alkylphosphocholine Drugs (info) Allergen Immunotherapies (info) Allylamine Antifungals (info) Alpha Agonist / Lubricant Combinations (info) Alpha Blockers (info) Alpha Glucosidase Inhibitors (info) Alpha Hydroxy Acids (info) Alpha-1 Agonists (info)...
The promoter methylation of the O 6 -methylguanine methyltransferase gene has been reported as prognostic as well as predictive for alkylating agents such as temozolomide in glioblastoma. Partly due to technical difficulties in detection of methylation with PCR, the results of studies are not ...
Chemotherapy antineoplastic agents can be divided into alkylating agents, metalloplatinum, plant drugs, antimetabolite, antineoplastic antibiotics, antineoplastic hormones, molecular targeted agents, and peptides, This article reviews the current drug characteristics, mechanism of action and research directions ...
Antineoplastic Agents, AlkylatingTumor Markers, BiologicalACTH-Secreting Pituitary AdenomaPituitary tumours, the most frequent intracranial tumour, are historically considered benign. However, various pieces of clinical evidence and recent advances in pathological and molecular analyses sugge...
Additionally, the various therapies in use; radiotherapy alone and combined with chemotherapy, chemotherapy with single alkylating agents such as chlorambucil and combination therapies, autologous and allogenic bone marrow transplantation, and therapy with purine analogs, such as chlorodeoxyadenosine and ...