An alkylating agent is any type of chemical substance that will add an alkyl group to another molecule in the chemical reaction...
Taxotere (docetaxel) is in a class of chemotherapy drugs known as taxanes, which attack cancer cells and prevent their growth. Cytoxan (cyclophosphamide) is an alkylating agent that works by damaging the DNA in cancer cells. We talked to experts about who might be a candidate for TC chemothera...
Cyclophosphamide is the most commonly used alkylating agent class of antitumor drugs, cell cycle non-specific cytotoxic drugs. After entry into the body, cyclophosphamide is decomposed into phosphoramide nitrogen mustard under the catalysis of liver microsomal enzyme, resulting in cytotoxic effect on tumor...
N-Nitroso is a substance that is a teratogen, mutagen, and carcinogen. Carrying a full designation as N-Nitroso-N-Methylurea, the substance is more commonly referred to as simply MNU. N-Nitroso is understood to be an alkylating agent that can be extremely toxic to humans. Exposure to N-...
N,N-Diisopropylethylamine is also known as Hunig’s base and abbreviated as DIPEA or DIEA, N,N-Diisopropylethylamine is a sterically hindered amine and an organic compound. The colourless liquid was named as Hung’s base after Siegfried Hunig, a German chemist. It is noteworthy that the co...
Which of the following is an alkylating agent used to treat leukemias and lymphomas prior to bone marrow transplantation? a) Methotrexate b) Busulfan c) Salicylates d) Acetaminophen What functional groups are present in progesterone? It is an inhibitor of Krebs cycle: a) Acetaminophen b) Salicyl...
The article presents a list of commonly used rescue protocols for lymphoma, a disease which is considered to be the third most common cancer in dogs. The list includes Mitoxantrone, labeled as one effective treatment for the disease; CCNU or L'asparaginase, an alkylating agent and considered to...
Cyclophosphamide–an alkylating agent chemo drug that also can damage the heart. Cyclophosphamide is typically used to treat bone, breast, leukemia, lymphoma, myeloma, ovarian, sarcomas, and skin cancers. Targeted therapy– these drugs also can cause heart damage. Examples of targeted therapy drugs ...
FITC is thought to be incompatible with GC due to the poor volatility and the presence of the carboxylic acid of fluorescein. Another disadvantage of the GC methods is the longer run time compared to LC, where run times can be less than 10 min. An advantage that FITC has over PITC and ...
Cyclophosphamide is the most commonly used alkylating agent class of antitumor drugs, cell cycle non-specific cytotoxic drugs. After entry into the body, cyclophosphamide is decomposed into phosphoramide nitrogen mustard under the catalysis of liver microsomal enzyme, resulting in cytotoxic effect on tumor...