Alkylating AgentsAlkylating agents ( al- ka- LAYT- ing AY- jints) are a family of anticancer drugs that interfere with cell's DNA and inhibit cancer cell growth. They are so named because of their ability to add...doi:10.1007/978-3-662-46875-3_182Sreerama, Lakshmaiah...
Alkylating agents are small molecules that can covalently bind an alkyl group to electron-rich nucleophilic moieties to form adduct and exert cytotoxic effect on cancer cells by binding to DNA molecules. From: How Synthetic Drugs Work, 2023 ...
DNA adducts from chemotherapeutic agents - ScienceDirect The guiding principle of early work was the hypothesis that the anti-cancer alkylating drugs acted through their ability to cross-link macromolecules essen... PD Lawley,DH Phillips - 《Mutat Res》 被引量: 391发表: 1996年 Cinnamic acid deriv...
The cellular pharmacology of the mitomycin bioreductive alkylating agents is complex. This reflects in part the chemical characteristics of these quinones,
Synthesis of heterocyclic compounds as potential anticancer agents Cancer is one of the leading causes of death in the western world today. This work looks at first the development of modern anticancer drugs and their draw... LA Stewart 被引量: 0发表: 1996年 Recent Progress in the Development...
a压力会成为动力,促使你成功 正在翻译,请等待...[translate] aN-alkylating agents and studied their Krafft points N烷基化的代理和学习他们的Krafft点[translate]
As retarded the growth of HBL-2 cells inoculated subcutaneously into anticipated, bendamustine increased the expression of these immunodeficient mice at concentrations that did not affect tumor genes stronger than did romidepsin, which could not inhibit SIRT7 growth as single agents. Because romidepsin ...
Design, Synthesis, and Evaluation of Latent Alkylating Agents Activated by Glutathione S -Transferase In search of compounds with improved specificity for targeting the important cancer-associated P1-1 glutathione S-transferase (GST) isozyme, new analogs 4 ... A Satyam,MD Hocker,KA Kane-Maguire,....
These agents were selected because they are used widely in human cancer therapy. Treated mice received a single 6-week course of 100 mg/kg/wk of either agent, a schedule which approaches the maximally tolerated doses. Cyclophosphamide (CY) was administered by intraperitoneal injection whereas ...
Alkylating Agent An alkylating agent alkylates other molecules; many chemical mutagens and carcinogens are alkylating agents. The mutationally most effective alkylation site in DNA is the O6site of guanine. O6-alkylguanine can pair with either cytosine, or thymine, resulting in a substitution ...